Protein profile

KP13_03347

Sec-independent protein translocase protein tatE

Genome: KpKP13

Gene: AHE45726.1 tatE Structure source: AlphaFold + ColabFold UniProt A0A0H3GQ13
Export view
Amino acids 68
Annotations 5
Features 15
PDB binders 0
Druggability 0.215

Overview

Basic information about this protein and its source genome.

Accession
KP13_03347
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45726.1 tatE
Status
annotated
Amino acids
68
Structure source
AlphaFold + ColabFold
GO
GO:0015031 The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0043953 The process in which folded proteins are transported across cytoplasmic membranes of bacteria and membranes of organelles derived from bacteria (chloroplasts and mitochondria) by the TAT complex. GO:0033281 A complex of three proteins integral to the cytoplasmic membrane of bacteria and membranes of organelles derived from bacteria (chloroplasts and mitochondria) involved in membrane transport of folded proteins. GO:0008320 Enables the transfer of a protein from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
50.0
DEG E-value
8.71e-14
Localization
CytoplasmicMembrane
ColabFold pLDDT
79.95

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.215
Structure A0A0H3GQ13
Pocket Pocket 5
P2Rank
Structure A0A0H3GQ13
Pocket No pockets
ColabFold model
FPocket 0.598 · Pocket 3
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 141 / 4744 genomes with a hit
Normalized 0.03

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0015031 The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0043953 The process in which folded proteins are transported across cytoplasmic membranes of bacteria and membranes of organelles derived from bacteria (chloroplasts and mitochondria) by the TAT complex.
  • GO:0033281 A complex of three proteins integral to the cytoplasmic membrane of bacteria and membranes of organelles derived from bacteria (chloroplasts and mitochondria) involved in membrane transport of folded proteins.
  • GO:0008320 Enables the transfer of a protein from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

15 records
Show feature table
Start End DB Term Name
6 22 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 67 PANTHER PTHR42982 SEC-INDEPENDENT PROTEIN TRANSLOCASE PROTEIN TATA
4 48 NCBIfam TIGR01411 twin-arginine translocase TatA/TatE family subunit
4 48 InterPro IPR006312 Sec-independent protein translocase protein TatA/E
1 5 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
23 68 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1 68 Hamap MF_00236 Sec-independent protein translocase protein TatA [tatA].
1 68 InterPro IPR006312 Sec-independent protein translocase protein TatA/E
4 21 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 68 Hamap MF_00903 Probable Sec-independent protein translocase protein TatE [tatE].
1 68 InterPro IPR024905 Sec-independent protein translocase protein TatE
4 54 Pfam PF02416 mttA/Hcf106 family
4 54 InterPro IPR003369 Sec-independent protein translocase protein TatA/B/E
1 47 Gene3D G3DSA:1.20.5.3310 -
46 68 MobiDBLite mobidb-lite consensus disorder prediction

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GQ13
AlphaFold — — full sequence — Viewing
ColabFold KP13_03347
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
5 0.215