Protein profile

KP13_03355

Universal stress protein G

Genome: KpKP13

Gene: AHE45734.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GLC0
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Amino acids 142
Annotations 0
Features 13
PDB binders 0
Druggability 0.539

Overview

Basic information about this protein and its source genome.

Accession
KP13_03355
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45734.1
Status
annotated
Amino acids
142
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
40.411
DEG E-value
2.1600000000000003e-27
Localization
Cytoplasmic
ColabFold pLDDT
88.2

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.539
Structure A0A0H3GLC0
Pocket Pocket 2
P2Rank 0.051
Structure A0A0H3GLC0
Pocket Pocket 1
ColabFold model
FPocket 0.355 · Pocket 5
P2Rank 0.076 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 61 / 4744 genomes with a hit
Normalized 0.013

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
1 142 SUPERFAMILY SSF52402 Adenine nucleotide alpha hydrolases-like
2 20 PRINTS PR01438 Universal stress protein signature
2 20 InterPro IPR006015 Universal stress protein A family
103 115 PRINTS PR01438 Universal stress protein signature
103 115 InterPro IPR006015 Universal stress protein A family
120 142 PRINTS PR01438 Universal stress protein signature
120 142 InterPro IPR006015 Universal stress protein A family
59 142 PANTHER PTHR46268 STRESS RESPONSE PROTEIN NHAX
1 142 Pfam PF00582 Universal stress protein family
1 142 InterPro IPR006016 UspA
1 142 Gene3D G3DSA:3.40.50.620 HUPs
1 142 InterPro IPR014729 Rossmann-like alpha/beta/alpha sandwich fold
17 141 CDD cd00293 USP_Like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GLC0
AlphaFold — — full sequence — Viewing
ColabFold KP13_03355
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.208
1 0.177
3 0.025
5 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.38 0.051