Protein profile

KP13_03358

Thiol:disulfide interchange protein dsbG

Genome: KpKP13

Gene: AHE45737.1 dsbG Structure source: AlphaFold + ColabFold UniProt A0A0H3GJX2
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Amino acids 249
Annotations 1
Features 19
PDB binders 0
Druggability 0.101

Overview

Basic information about this protein and its source genome.

Accession
KP13_03358
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45737.1 dsbG
Status
annotated
Amino acids
249
Structure source
AlphaFold + ColabFold
GO
GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Periplasmic
ColabFold pLDDT
92.66

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.101
Structure A0A0H3GJX2
Pocket Pocket 13
P2Rank 0.032
Structure A0A0H3GJX2
Pocket Pocket 1
ColabFold model
FPocket 0.054 · Pocket 3
P2Rank 0.039 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 63 / 4744 genomes with a hit
Normalized 0.013

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).

Sequence Features

Domain/signature hits from InterPro and related databases.

19 records
Show feature table
Start End DB Term Name
32 241 CDD cd03020 DsbA_DsbC_DsbG
32 241 InterPro IPR033954 Disulphide bond isomerase, DsbC/G
1 17 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
84 242 SUPERFAMILY SSF52833 Thioredoxin-like
84 242 InterPro IPR036249 Thioredoxin-like superfamily
20 89 Gene3D G3DSA:3.10.450.70 -
20 89 InterPro IPR009094 Disulphide bond isomerase DsbC/G, N-terminal domain superfamily
115 242 Pfam PF13098 Thioredoxin-like domain
115 242 InterPro IPR012336 Thioredoxin-like fold
5 13 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
19 77 SUPERFAMILY SSF54423 DsbC/DsbG N-terminal domain-like
19 77 InterPro IPR009094 Disulphide bond isomerase DsbC/G, N-terminal domain superfamily
18 249 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 247 PANTHER PTHR35272 THIOL:DISULFIDE INTERCHANGE PROTEIN DSBC-RELATED
104 249 Gene3D G3DSA:3.40.30.10 Glutaredoxin
1 17 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
1 17 Phobius SIGNAL_PEPTIDE Signal peptide region
14 17 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 4 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GJX2
AlphaFold — — full sequence — Viewing
ColabFold KP13_03358
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.75 0.032
2 1.09 0.007