Protein profile

KP13_03360

hypothetical protein

Genome: KpKP13

Gene: AHE45739.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GLB6
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Amino acids 372
Annotations 2
Features 10
PDB binders 0
Druggability 0.668

Overview

Basic information about this protein and its source genome.

Accession
KP13_03360
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45739.1
Status
annotated
Amino acids
372
Structure source
AlphaFold + ColabFold
GO
GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0071453 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
91.89

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.668
Structure A0A0H3GLB6
Pocket Pocket 29
P2Rank 0.903
Structure A0A0H3GLB6
Pocket Pocket 1
ColabFold model
FPocket 0.611 · Pocket 24
P2Rank 0.876 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 63 / 4744 genomes with a hit
Normalized 0.013

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
  • GO:0071453 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen.

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records
Show feature table
Start End DB Term Name
32 236 Pfam PF01507 Phosphoadenosine phosphosulfate reductase family
32 236 InterPro IPR002500 Phosphoadenosine phosphosulphate reductase
239 341 Pfam PF11922 Domain of unknown function (DUF3440)
239 341 InterPro IPR021845 Protein of unknown function DUF3440
31 240 CDD cd01713 PAPS_reductase
31 240 InterPro IPR002500 Phosphoadenosine phosphosulphate reductase
5 372 PANTHER PTHR30083 UNCHARACTERIZED
10 239 Gene3D G3DSA:3.40.50.620 HUPs
10 239 InterPro IPR014729 Rossmann-like alpha/beta/alpha sandwich fold
14 234 SUPERFAMILY SSF52402 Adenine nucleotide alpha hydrolases-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GLB6
AlphaFold — — full sequence — Viewing
ColabFold KP13_03360
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
29 0.668

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 13.34 0.682
2 2.58 0.073
3 2.45 0.067
4 1.59 0.025
5 1.29 0.014