Protein profile

KP13_03361

ParB-like nuclease domain-containing protein

Genome: KpKP13

Gene: AHE45740.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GPU5
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Amino acids 212
Annotations 1
Features 9
PDB binders 0
Druggability 0.261

Overview

Basic information about this protein and its source genome.

Accession
KP13_03361
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45740.1
Status
annotated
Amino acids
212
Structure source
AlphaFold + ColabFold
GO
GO:0071453 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
86.48

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.261
Structure A0A0H3GPU5
Pocket Pocket 7
P2Rank 0.409
Structure A0A0H3GPU5
Pocket Pocket 1
ColabFold model
FPocket 0.512 · Pocket 8
P2Rank 0.417 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 77 / 4744 genomes with a hit
Normalized 0.016

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0071453 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
50 127 Gene3D G3DSA:3.90.1530.10 -
46 148 CDD cd16397 IbrB_like
14 205 PANTHER PTHR30083 UNCHARACTERIZED
52 148 Pfam PF02195 ParB/Sulfiredoxin domain
52 148 InterPro IPR003115 ParB/Sulfiredoxin
51 149 SMART SM00470 ParB_7
51 149 InterPro IPR003115 ParB/Sulfiredoxin
49 182 SUPERFAMILY SSF110849 ParB/Sulfiredoxin
49 182 InterPro IPR036086 ParB/Sulfiredoxin superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GPU5
AlphaFold — — full sequence — Viewing
ColabFold KP13_03361
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
7 0.261

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 5.38 0.255
2 4.75 0.209
3 1.22 0.011