Protein profile

KP13_03376

putative purine catabolism regulatory protein

Genome: KpKP13

Gene: AHE45755.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GLA2
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Amino acids 411
Annotations 1
Features 11
PDB binders 0
Druggability 0.444

Overview

Basic information about this protein and its source genome.

Accession
KP13_03376
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45755.1
Status
annotated
Amino acids
411
Structure source
AlphaFold + ColabFold
GO
GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
89.56

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.444
Structure A0A0H3GLA2
Pocket Pocket 23
P2Rank 0.035
Structure A0A0H3GLA2
Pocket Pocket 1
ColabFold model
FPocket 0.839 · Pocket 27
P2Rank 0.07 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 12 / 4744 genomes with a hit
Normalized 0.003

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
7 126 Pfam PF07905 Purine catabolism regulatory protein-like family
7 126 InterPro IPR012914 Purine catabolism PurC-like domain
346 375 SUPERFAMILY SSF46689 Homeodomain-like
346 375 InterPro IPR009057 Homeobox-like domain superfamily
272 404 Gene3D G3DSA:1.10.10.2840 -
272 404 InterPro IPR042070 PucR C-terminal helix-turn-helix domain superfamily
341 398 Pfam PF13556 PucR C-terminal helix-turn-helix domain
341 398 InterPro IPR025736 PucR C-terminal helix-turn-helix domain
116 404 PANTHER PTHR33744 CARBOHYDRATE DIACID REGULATOR
147 288 Pfam PF17853 GGDEF-like domain
147 288 InterPro IPR041522 CdaR, GGDEF-like domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GLA2
AlphaFold — — full sequence — Viewing
ColabFold KP13_03376
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
23 0.444

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.51 0.022
2 1.44 0.019