Protein profile

KP13_03383

Methylthioribose kinase

Genome: KpKP13

Gene: mtnK AHE45762.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GPU2
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Amino acids 399
Annotations 5
Features 13
PDB binders 0
Druggability 0.486

Overview

Basic information about this protein and its source genome.

Accession
KP13_03383
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
mtnK AHE45762.1
Status
annotated
Amino acids
399
Structure source
AlphaFold + ColabFold
EC
2.7.1.100
GO
GO:0046522 Catalysis of the reaction: S-methyl-5-thio-D-ribose + ATP = S-methyl-5-thio-alpha-D-ribose 1-phosphate + ADP + 2 H+. GO:0009086 OBSOLETE. The chemical reactions and pathways resulting in the de novo formation of L-methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0019509 OBSOLETE. The generation of L-methionine (2-amino-4-(methylthio)butanoic acid) from methylthioadenosine.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
97.07

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.486
Structure A0A0H3GPU2
Pocket Pocket 11
P2Rank 0.967
Structure A0A0H3GPU2
Pocket Pocket 1
ColabFold model
FPocket 0.504 · Pocket 10
P2Rank 0.971 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 63 / 4744 genomes with a hit
Normalized 0.013

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 4 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

4
  • GO:0046522 Catalysis of the reaction: S-methyl-5-thio-D-ribose + ATP = S-methyl-5-thio-alpha-D-ribose 1-phosphate + ADP + 2 H+.
  • GO:0009086 OBSOLETE. The chemical reactions and pathways resulting in the de novo formation of L-methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.
  • GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
  • GO:0019509 OBSOLETE. The generation of L-methionine (2-amino-4-(methylthio)butanoic acid) from methylthioadenosine.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
8 397 PANTHER PTHR34273 METHYLTHIORIBOSE KINASE
4 395 NCBIfam TIGR01767 S-methyl-5-thioribose kinase
4 395 InterPro IPR009212 Methylthioribose kinase
1 115 Gene3D G3DSA:3.30.200.20 Phosphorylase Kinase; domain 1
32 263 Pfam PF01636 Phosphotransferase enzyme family
32 263 InterPro IPR002575 Aminoglycoside phosphotransferase
1 397 SUPERFAMILY SSF56112 Protein kinase-like (PK-like)
1 397 InterPro IPR011009 Protein kinase-like domain superfamily
116 398 Gene3D G3DSA:3.90.1200.10 -
2 399 Hamap MF_01683 Methylthioribose kinase [mtnK].
2 399 InterPro IPR009212 Methylthioribose kinase
1 399 PIRSF PIRSF031134 MTRK
1 399 InterPro IPR009212 Methylthioribose kinase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GPU2
AlphaFold — — full sequence — Viewing
ColabFold KP13_03383
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
11 0.486
1 0.072
2 0.001
4 0.001

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 49.81 0.967
2 4.09 0.135
3 3.1 0.083
4 2.68 0.064
5 0.93 0.004