Protein profile

KP13_03391

plasmid stabilization system, cytotoxic translational repressor protein

Genome: KpKP13

Gene: AHE45769.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GPS1
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Amino acids 100
Annotations 0
Features 6
PDB binders 0
Druggability 0.515

Overview

Basic information about this protein and its source genome.

Accession
KP13_03391
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45769.1
Status
annotated
Amino acids
100
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
74.42

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.515
Structure A0A0H3GPS1
Pocket Pocket 1
P2Rank 0.01
Structure A0A0H3GPS1
Pocket Pocket 1
ColabFold model
FPocket 0.346 · Pocket 5
P2Rank 0.023 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 17 / 4744 genomes with a hit
Normalized 0.004

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

6 records
Show feature table
Start End DB Term Name
1 86 Gene3D G3DSA:3.30.2310.20 -
1 86 InterPro IPR035093 Toxin-antitoxin system, RelE/ParE toxin domain superfamily
3 80 Pfam PF05016 ParE toxin of type II toxin-antitoxin system, parDE
3 80 InterPro IPR007712 Toxin-antitoxin system, RelE/ParE toxin family
1 80 SUPERFAMILY SSF143011 RelE-like
1 80 InterPro IPR035093 Toxin-antitoxin system, RelE/ParE toxin domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GPS1
AlphaFold — — full sequence — Viewing
ColabFold KP13_03391
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.515
2 0.047
8 0.03
4 0.006

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.21 0.01