Protein profile

KP13_03411

putative enterobactin synthetase, component D

Genome: KpKP13

Gene: AHE45788.1 Structure source: AlphaFold + ColabFold UniProt A0A263K9T7
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Amino acids 219
Annotations 6
Features 16
PDB binders 1
Druggability 0.254

Overview

Basic information about this protein and its source genome.

Accession
KP13_03411
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45788.1
Status
annotated
Amino acids
219
Structure source
AlphaFold + ColabFold
GO
GO:0016780 Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor). GO:0008897 Catalysis of the reaction: CoA + substrate-serine = adenosine 3',5'-bisphosphate + substrate-serine-4'-phosphopantetheine. The transfer of the 4'-phosphopantetheine (Ppant) co-factor from coenzyme A to the hydroxyl side chain of the serine residue of acyl- or peptidyl-carrier protein (ACP or PCP) to convert them from the apo to the holo form. GO:0000287 Binding to a magnesium (Mg) ion. GO:0009239 The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. GO:0009366 A multienzyme complex usually composed of four proteins, EntB, EntD, EntE and EntF. Plays a role in the enterobactin biosynthesis pathway. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
54.696
DEG E-value
5.15e-63
Localization
Unknown
ColabFold pLDDT
95.21

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.254
Structure A0A263K9T7
Pocket Pocket 8
P2Rank 0.57
Structure A0A263K9T7
Pocket Pocket 1
ColabFold model
FPocket 0.423 · Pocket 1
P2Rank 0.266 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 34 / 4744 genomes with a hit
Normalized 0.007

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6
  • GO:0016780 Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor).
  • GO:0008897 Catalysis of the reaction: CoA + substrate-serine = adenosine 3',5'-bisphosphate + substrate-serine-4'-phosphopantetheine. The transfer of the 4'-phosphopantetheine (Ppant) co-factor from coenzyme A to the hydroxyl side chain of the serine residue of acyl- or peptidyl-carrier protein (ACP or PCP) to convert them from the apo to the holo form.
  • GO:0000287 Binding to a magnesium (Mg) ion.
  • GO:0009239 The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway.
  • GO:0009366 A multienzyme complex usually composed of four proteins, EntB, EntD, EntE and EntF. Plays a role in the enterobactin biosynthesis pathway.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records
Show feature table
Start End DB Term Name
42 120 Gene3D G3DSA:3.90.470.20 -
42 120 InterPro IPR037143 4'-phosphopantetheinyl transferase domain superfamily
102 188 SUPERFAMILY SSF56214 4'-phosphopantetheinyl transferase
102 188 InterPro IPR037143 4'-phosphopantetheinyl transferase domain superfamily
103 191 Pfam PF01648 4'-phosphopantetheinyl transferase superfamily
103 191 InterPro IPR008278 4'-phosphopantetheinyl transferase domain
44 64 PRINTS PR01399 Enterobactin synthetase component D signature
44 64 InterPro IPR003542 Enterobactin synthetase-like, component D
146 162 PRINTS PR01399 Enterobactin synthetase component D signature
146 162 InterPro IPR003542 Enterobactin synthetase-like, component D
73 91 PRINTS PR01399 Enterobactin synthetase component D signature
73 91 InterPro IPR003542 Enterobactin synthetase-like, component D
44 100 Pfam PF17837 4'-phosphopantetheinyl transferase N-terminal domain
44 100 InterPro IPR041354 4'-phosphopantetheinyl transferase, N-terminal domain
7 215 PANTHER PTHR38096 ENTEROBACTIN SYNTHASE COMPONENT D
7 215 InterPro IPR003542 Enterobactin synthetase-like, component D

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A263K9T7
AlphaFold — — full sequence — Viewing
ColabFold KP13_03411
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
8 0.254

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 3.38 0.121
2 2.03 0.045

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

33 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
FD7
6CT5
O33336 262.4 Da LogP 2.48 TPSA 77.0 ✓ Ro5 ✓ Clean [H]/N=C(/NCC)\NC(=O)Nc1c(cccc1CC)CC

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.