Protein profile

KP13_03426

Inhibitor of vertebrate lysozyme

Genome: KpKP13

Gene: AHE45803.1 ivy Structure source: AlphaFold + ColabFold UniProt A0A422Z157
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Amino acids 175
Annotations 2
Features 7
PDB binders 0
Druggability 0.285

Overview

Basic information about this protein and its source genome.

Accession
KP13_03426
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45803.1 ivy
Status
annotated
Amino acids
175
Structure source
AlphaFold + ColabFold
GO
GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:0043086 Any process that stops or reduces the activity of an enzyme.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Periplasmic
ColabFold pLDDT
83.67

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.285
Structure A0A422Z157
Pocket Pocket 12
P2Rank 0.028
Structure A0A422Z157
Pocket Pocket 1
ColabFold model
FPocket 0.588 · Pocket 3
P2Rank 0.026 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 17 / 4744 genomes with a hit
Normalized 0.004

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
  • GO:0043086 Any process that stops or reduces the activity of an enzyme.

Sequence Features

Domain/signature hits from InterPro and related databases.

7 records
Show feature table
Start End DB Term Name
20 172 PIRSF PIRSF009103 Ivy
20 172 InterPro IPR014453 Inhibitor of vertebrate lysozyme
49 174 SUPERFAMILY SSF89872 Inhibitor of vertebrate lysozyme, Ivy
49 174 InterPro IPR036501 Inhibitor of vertebrate lysozyme superfamily
47 175 Gene3D G3DSA:3.40.1420.10 Inhibitor of vertebrate lysozyme
47 175 InterPro IPR036501 Inhibitor of vertebrate lysozyme superfamily
57 170 Pfam PF08816 Inhibitor of vertebrate lysozyme (Ivy)

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A422Z157
AlphaFold — — full sequence — Viewing
ColabFold KP13_03426
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
12 0.285

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 0.99 0.005
2 0.8 0.002