Protein profile

KP13_03433

putative ABC transport system permease component

Genome: KpKP13

Gene: AHE45808.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GJT0
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Amino acids 350
Annotations 4
Features 32
PDB binders 0
Druggability 0.969

Overview

Basic information about this protein and its source genome.

Accession
KP13_03433
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45808.1
Status
annotated
Amino acids
350
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0071916 Enables the transfer of a dipeptide from one side of a membrane to the other. A dipeptide is a combination of two amino acids linked together by a peptide (-CO-NH-) bond.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
89.71

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.969
Structure A0A0H3GJT0
Pocket Pocket 2
P2Rank 0.677
Structure A0A0H3GJT0
Pocket Pocket 1
ColabFold model
FPocket 0.759 · Pocket 13
P2Rank 0.551 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 74 / 4744 genomes with a hit
Normalized 0.016

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0071916 Enables the transfer of a dipeptide from one side of a membrane to the other. A dipeptide is a combination of two amino acids linked together by a peptide (-CO-NH-) bond.

Sequence Features

Domain/signature hits from InterPro and related databases.

32 records
Show feature table
Start End DB Term Name
153 173 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
319 342 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
21 43 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
277 299 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
117 139 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
232 276 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
129 350 Pfam PF00528 Binding-protein-dependent transport system inner membrane component
129 350 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
21 350 PANTHER PTHR43163 DIPEPTIDE TRANSPORT SYSTEM PERMEASE PROTEIN DPPB-RELATED
277 299 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
343 350 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
21 42 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
151 173 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
215 237 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
111 333 CDD cd06261 TM_PBP2
111 333 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
215 231 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
300 318 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
174 214 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
312 334 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 20 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
107 335 SUPERFAMILY SSF161098 MetI-like
107 335 InterPro IPR035906 MetI-like superfamily
117 141 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
102 344 Gene3D G3DSA:1.10.3720.10 -
102 344 InterPro IPR035906 MetI-like superfamily
21 92 Pfam PF19300 Binding-prot-dependent transport system membrane comp, N-term
21 92 InterPro IPR045621 ABC transporter type 1, GsiC-like, N-terminal domain
142 152 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
43 116 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
111 342 ProSiteProfiles PS50928 ABC transporter integral membrane type-1 domain profile.
111 342 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GJT0
AlphaFold — — full sequence — Viewing
ColabFold KP13_03433
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.969
7 0.312
10 0.208

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 9.76 0.525