Protein profile

KP13_03434

putative ABC transport system permease component

Genome: KpKP13

Gene: AHE45809.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GTM5
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Amino acids 277
Annotations 4
Features 32
PDB binders 0
Druggability 0.886

Overview

Basic information about this protein and its source genome.

Accession
KP13_03434
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45809.1
Status
annotated
Amino acids
277
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0071916 Enables the transfer of a dipeptide from one side of a membrane to the other. A dipeptide is a combination of two amino acids linked together by a peptide (-CO-NH-) bond.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
46.617
DEG E-value
2.99e-77
Localization
CytoplasmicMembrane
ColabFold pLDDT
92.58

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.886
Structure A0A0H3GTM5
Pocket Pocket 6
P2Rank 0.268
Structure A0A0H3GTM5
Pocket Pocket 1
ColabFold model
FPocket 0.605 · Pocket 1
P2Rank 0.216 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 74 / 4744 genomes with a hit
Normalized 0.016

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0071916 Enables the transfer of a dipeptide from one side of a membrane to the other. A dipeptide is a combination of two amino acids linked together by a peptide (-CO-NH-) bond.

Sequence Features

Domain/signature hits from InterPro and related databases.

32 records
Show feature table
Start End DB Term Name
13 35 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
8 276 PANTHER PTHR43386 OLIGOPEPTIDE TRANSPORT SYSTEM PERMEASE PROTEIN APPC
1 14 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
224 242 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
125 147 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
152 170 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
82 104 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
6 53 Pfam PF12911 N-terminal TM domain of oligopeptide transport permease C
6 53 InterPro IPR025966 Oligopeptide transport permease C-like, N-terminal domain
125 151 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
243 264 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
265 277 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
38 78 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
201 223 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
76 265 ProSiteProfiles PS50928 ABC transporter integral membrane type-1 domain profile.
76 265 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
15 37 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
94 274 Pfam PF00528 Binding-protein-dependent transport system inner membrane component
94 274 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
79 104 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
66 272 Gene3D G3DSA:1.10.3720.10 -
66 272 InterPro IPR035906 MetI-like superfamily
80 257 CDD cd06261 TM_PBP2
80 257 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
1 39 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
200 222 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
71 257 SUPERFAMILY SSF161098 MetI-like
71 257 InterPro IPR035906 MetI-like superfamily
195 200 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
171 194 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
105 124 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
243 265 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GTM5
AlphaFold — — full sequence — Viewing
ColabFold KP13_03434
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
6 0.886

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 4.27 0.176
2 3.28 0.115
3 2.13 0.049
4 1.77 0.033