Protein profile

KP13_03451

putative binding-protein-dependent transport system protein

Genome: KpKP13

Gene: AHE45827.1 Structure source: AlphaFold + ColabFold UniProt W9B540
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Amino acids 317
Annotations 4
Features 32
PDB binders 0
Druggability 0.752

Overview

Basic information about this protein and its source genome.

Accession
KP13_03451
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45827.1
Status
annotated
Amino acids
317
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0071916 Enables the transfer of a dipeptide from one side of a membrane to the other. A dipeptide is a combination of two amino acids linked together by a peptide (-CO-NH-) bond.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
88.57

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.752
Structure W9B540
Pocket Pocket 1
P2Rank 0.631
Structure W9B540
Pocket Pocket 1
ColabFold model
FPocket 0.836 · Pocket 11
P2Rank 0.607 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 11 / 4744 genomes with a hit
Normalized 0.002

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0071916 Enables the transfer of a dipeptide from one side of a membrane to the other. A dipeptide is a combination of two amino acids linked together by a peptide (-CO-NH-) bond.

Sequence Features

Domain/signature hits from InterPro and related databases.

32 records
Show feature table
Start End DB Term Name
242 264 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 76 Pfam PF19300 Binding-prot-dependent transport system membrane comp, N-term
1 76 InterPro IPR045621 ABC transporter type 1, GsiC-like, N-terminal domain
202 242 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
101 123 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
31 100 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
7 29 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
113 315 Pfam PF00528 Binding-protein-dependent transport system inner membrane component
113 315 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
284 306 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
97 279 CDD cd06261 TM_PBP2
97 279 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
162 180 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
95 307 ProSiteProfiles PS50928 ABC transporter integral membrane type-1 domain profile.
95 307 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
243 264 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
7 30 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
101 123 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
135 161 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
142 164 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
124 134 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
307 317 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1 316 PANTHER PTHR43163 DIPEPTIDE TRANSPORT SYSTEM PERMEASE PROTEIN DPPB-RELATED
1 6 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
86 314 Gene3D G3DSA:1.10.3720.10 -
86 314 InterPro IPR035906 MetI-like superfamily
91 298 SUPERFAMILY SSF161098 MetI-like
91 298 InterPro IPR035906 MetI-like superfamily
179 201 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
181 201 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
265 283 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
284 306 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_W9B540
AlphaFold — — full sequence — Viewing
ColabFold KP13_03451
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.752
27 0.679
20 0.293

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 9.62 0.518
2 5.17 0.239
3 2.33 0.06
4 2.0 0.043
5 1.53 0.022