Protein profile

KP13_03456

Secretion protein HlyD family

Genome: KpKP13

Gene: AHE45832.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GPD5
Export view
Amino acids 359
Annotations 3
Features 20
PDB binders 0
Druggability 0.598

Overview

Basic information about this protein and its source genome.

Accession
KP13_03456
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45832.1
Status
annotated
Amino acids
359
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
87.71

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.598
Structure A0A0H3GPD5
Pocket Pocket 1
P2Rank 0.031
Structure A0A0H3GPD5
Pocket Pocket 1
ColabFold model
FPocket 0.797 · Pocket 2
P2Rank 0.164 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 25 / 4744 genomes with a hit
Normalized 0.005

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

20 records
Show feature table
Start End DB Term Name
44 278 SUPERFAMILY SSF111369 HlyD-like secretion proteins
1 7 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
267 358 Gene3D G3DSA:2.40.420.20 -
1 20 SignalP_EUK SignalP-noTM SignalP-noTM
102 273 Pfam PF16576 Barrel-sandwich domain of CusB or HlyD membrane-fusion
102 273 InterPro IPR032317 RND efflux pump, membrane fusion protein, barrel-sandwich domain
7 357 PANTHER PTHR30158 ACRA/E-RELATED COMPONENT OF DRUG EFFLUX TRANSPORTER
1 23 Phobius SIGNAL_PEPTIDE Signal peptide region
53 196 Gene3D G3DSA:2.40.50.100 -
1 23 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
20 23 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 23 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
94 121 Coils Coil Coil
7 29 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
24 359 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
47 266 Gene3D G3DSA:2.40.30.170 -
8 19 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
88 161 Gene3D G3DSA:1.10.287.470 Helix hairpin bin
29 357 NCBIfam TIGR01730 efflux RND transporter periplasmic adaptor subunit
29 357 InterPro IPR006143 RND efflux pump, membrane fusion protein

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GPD5
AlphaFold — — full sequence — Viewing
ColabFold KP13_03456
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
8 0.06
19 0.014
3 0.001
7 0.001

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.89 0.031
2 0.84 0.003