Protein profile

KP13_32066

putative ramA repressor, RamR

Genome: KpKP13

Gene: AHE45838.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GJQ8
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Amino acids 193
Annotations 2
Features 19
PDB binders 0
Druggability 0.826

Overview

Basic information about this protein and its source genome.

Accession
KP13_32066
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45838.1
Status
annotated
Amino acids
193
Structure source
AlphaFold + ColabFold
GO
GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003723 Binding to an RNA molecule or a portion thereof.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
93.57

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.826
Structure A0A0H3GJQ8
Pocket Pocket 9
P2Rank 0.952
Structure A0A0H3GJQ8
Pocket Pocket 1
ColabFold model
FPocket 0.008 · Pocket 12
P2Rank 0.937 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 57 / 4744 genomes with a hit
Normalized 0.012

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0003723 Binding to an RNA molecule or a portion thereof.

Sequence Features

Domain/signature hits from InterPro and related databases.

19 records
Show feature table
Start End DB Term Name
25 55 ProSitePatterns PS01081 TetR-type HTH domain signature.
25 55 InterPro IPR023772 DNA-binding HTH domain, TetR-type, conserved site
1 11 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
13 58 Pfam PF00440 Bacterial regulatory proteins, tetR family
13 58 InterPro IPR001647 DNA-binding HTH domain, TetR-type
12 22 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 34 Phobius SIGNAL_PEPTIDE Signal peptide region
35 193 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 192 Gene3D G3DSA:1.10.357.10 Tetracycline Repressor, domain 2
23 34 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
2 185 PANTHER PTHR30055 HTH-TYPE TRANSCRIPTIONAL REGULATOR RUTR
13 26 PRINTS PR00455 TetR bacterial regulatory protein HTH signature
13 26 InterPro IPR001647 DNA-binding HTH domain, TetR-type
33 56 PRINTS PR00455 TetR bacterial regulatory protein HTH signature
33 56 InterPro IPR001647 DNA-binding HTH domain, TetR-type
7 66 ProSiteProfiles PS50977 TetR-type HTH domain profile.
7 66 InterPro IPR001647 DNA-binding HTH domain, TetR-type
3 76 SUPERFAMILY SSF46689 Homeodomain-like
3 76 InterPro IPR009057 Homeobox-like domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GJQ8
AlphaFold — — full sequence — Viewing
ColabFold KP13_32066
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
9 0.826

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 37.11 0.957