Protein profile

KP13_03471

RNA polymerase sigma factor 54, interaction domain-containing protein

Genome: KpKP13

Gene: AHE45847.1 Structure source: AlphaFold + ColabFold UniProt A0A377WIJ1
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Amino acids 122
Annotations 1
Features 7
PDB binders 0
Druggability 0.736

Overview

Basic information about this protein and its source genome.

Accession
KP13_03471
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45847.1
Status
annotated
Amino acids
122
Structure source
AlphaFold + ColabFold
GO
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
90.53

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.736
Structure A0A377WIJ1
Pocket Pocket 8
P2Rank 0.026
Structure A0A377WIJ1
Pocket Pocket 1
ColabFold model
FPocket 0.298 · Pocket 3
P2Rank 0.032 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 6 / 4744 genomes with a hit
Normalized 0.001

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Sequence Features

Domain/signature hits from InterPro and related databases.

7 records
Show feature table
Start End DB Term Name
17 122 ProSiteProfiles PS51372 PRD domain profile.
17 122 InterPro IPR011608 PRD domain
20 114 Gene3D G3DSA:1.10.1790.10 PRD domain
28 114 Pfam PF00874 PRD domain
28 114 InterPro IPR011608 PRD domain
20 113 SUPERFAMILY SSF63520 PTS-regulatory domain, PRD
20 113 InterPro IPR036634 PRD domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A377WIJ1
AlphaFold — — full sequence — Viewing
ColabFold KP13_03471
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
8 0.736
5 0.315
3 0.002
2 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.74 0.026