Protein profile

KP13_03475

Helix-turn-helix type 3 domain-containing protein

Genome: KpKP13

Gene: AHE45852.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GKZ7
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Amino acids 289
Annotations 1
Features 13
PDB binders 0
Druggability 0.391

Overview

Basic information about this protein and its source genome.

Accession
KP13_03475
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45852.1
Status
annotated
Amino acids
289
Structure source
AlphaFold + ColabFold
GO
GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
87.06

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.391
Structure A0A0H3GKZ7
Pocket Pocket 9
P2Rank 0.672
Structure A0A0H3GKZ7
Pocket Pocket 1
ColabFold model
FPocket 0.628 · Pocket 1
P2Rank 0.632 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 43 / 4744 genomes with a hit
Normalized 0.009

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
124 289 Gene3D G3DSA:3.30.450.180 -
21 100 Pfam PF13560 Helix-turn-helix domain
45 96 CDD cd00093 HTH_XRE
45 96 InterPro IPR001387 Cro/C1-type helix-turn-helix domain
25 97 SMART SM00530 mbf_short4
25 97 InterPro IPR001387 Cro/C1-type helix-turn-helix domain
15 286 PANTHER PTHR35010 BLL4672 PROTEIN-RELATED
120 286 Pfam PF17765 MmyB-like transcription regulator ligand binding domain
120 286 InterPro IPR041413 MmyB-like transcription regulator ligand binding
20 94 SUPERFAMILY SSF47413 lambda repressor-like DNA-binding domains
20 94 InterPro IPR010982 Lambda repressor-like, DNA-binding domain superfamily
15 96 Gene3D G3DSA:1.10.260.40 -
15 96 InterPro IPR010982 Lambda repressor-like, DNA-binding domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GKZ7
AlphaFold — — full sequence — Viewing
ColabFold KP13_03475
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
9 0.391
15 0.351
17 0.23
1 0.229

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 9.68 0.52
2 2.82 0.087
3 1.92 0.039