Protein profile

KP13_03481

Xylose isomerase-like, TIM barrel domain-containing protein

Genome: KpKP13

Gene: AHE45858.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GPI8
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Amino acids 340
Annotations 0
Features 6
PDB binders 0
Druggability 0.203

Overview

Basic information about this protein and its source genome.

Accession
KP13_03481
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45858.1
Status
annotated
Amino acids
340
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
96.51

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.203
Structure A0A0H3GPI8
Pocket Pocket 20
P2Rank 0.897
Structure A0A0H3GPI8
Pocket Pocket 1
ColabFold model
FPocket 0.363 · Pocket 12
P2Rank 0.913 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 62 / 4744 genomes with a hit
Normalized 0.013

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

6 records
Show feature table
Start End DB Term Name
29 321 Pfam PF01261 Xylose isomerase-like TIM barrel
29 321 InterPro IPR013022 Xylose isomerase-like, TIM barrel domain
8 323 SUPERFAMILY SSF51658 Xylose isomerase-like
8 323 InterPro IPR036237 Xylose isomerase-like superfamily
30 311 PANTHER PTHR12110 HYDROXYPYRUVATE ISOMERASE
19 324 Gene3D G3DSA:3.20.20.150 -

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GPI8
AlphaFold — — full sequence — Viewing
ColabFold KP13_03481
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
20 0.203

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 10.19 0.548
2 5.48 0.261
3 3.1 0.104
4 2.45 0.067
5 2.23 0.054