Protein profile

KP13_03485

WD40/YVTN repeat-like domain-containing protein

Genome: KpKP13

Gene: AHE45862.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GKY3
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Amino acids 360
Annotations 1
Features 13
PDB binders 0
Druggability 0.212

Overview

Basic information about this protein and its source genome.

Accession
KP13_03485
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45862.1
Status
annotated
Amino acids
360
Structure source
AlphaFold + ColabFold
GO
GO:0005515 Binding to a protein.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
40.373
DEG E-value
1.97e-75
Localization
Unknown
ColabFold pLDDT
90.84

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.212
Structure A0A0H3GKY3
Pocket Pocket 14
P2Rank 0.802
Structure A0A0H3GKY3
Pocket Pocket 1
ColabFold model
FPocket 0.469 · Pocket 10
P2Rank 0.793 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 38 / 4744 genomes with a hit
Normalized 0.008

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
29 360 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 20 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
1 19 ProSiteProfiles PS51257 Prokaryotic membrane lipoprotein lipid attachment site profile.
5 16 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
49 345 SUPERFAMILY SSF51004 C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase
49 345 InterPro IPR011048 Cytochrome cd1-nitrite reductase-like, haem d1 domain superfamily
40 357 Gene3D G3DSA:2.130.10.10 -
40 357 InterPro IPR015943 WD40/YVTN repeat-like-containing domain superfamily
1 28 Phobius SIGNAL_PEPTIDE Signal peptide region
17 28 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
157 356 PANTHER PTHR47197 PROTEIN NIRF
1 4 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1 25 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GKY3
AlphaFold — — full sequence — Viewing
ColabFold KP13_03485
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
14 0.212

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 4.73 0.208
2 4.57 0.197
3 2.35 0.061