Protein profile

KP13_03488

putative oxidoreductase protein

Genome: KpKP13

Gene: AHE45865.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GP94
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Amino acids 433
Annotations 1
Features 8
PDB binders 0
Druggability 0.982

Overview

Basic information about this protein and its source genome.

Accession
KP13_03488
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45865.1
Status
annotated
Amino acids
433
Structure source
AlphaFold + ColabFold
GO
GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
95.05

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.982
Structure A0A0H3GP94
Pocket Pocket 1
P2Rank 0.997
Structure A0A0H3GP94
Pocket Pocket 1
ColabFold model
FPocket 0.881 · Pocket 29
P2Rank 0.997 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 23 / 4744 genomes with a hit
Normalized 0.005

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
31 385 Gene3D G3DSA:3.50.50.60 -
31 385 InterPro IPR036188 FAD/NAD(P)-binding domain superfamily
27 387 PANTHER PTHR13847 SARCOSINE DEHYDROGENASE-RELATED
31 385 Pfam PF01266 FAD dependent oxidoreductase
31 385 InterPro IPR006076 FAD dependent oxidoreductase
125 346 Gene3D G3DSA:3.30.9.10 -
30 397 SUPERFAMILY SSF51905 FAD/NAD(P)-binding domain
30 397 InterPro IPR036188 FAD/NAD(P)-binding domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GP94
AlphaFold — — full sequence — Viewing
ColabFold KP13_03488
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.982
20 0.312

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 81.04 0.994
2 7.82 0.415
3 1.66 0.028
4 1.01 0.006