Protein profile

KP13_03493

Helix-turn-helix type 3 domain-containing protein

Genome: KpKP13

Gene: AHE45869.1 Structure source: AlphaFold + ColabFold UniProt A0A6A8EJH0
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Amino acids 120
Annotations 3
Features 14
PDB binders 0
Druggability 0.725

Overview

Basic information about this protein and its source genome.

Accession
KP13_03493
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45869.1
Status
annotated
Amino acids
120
Structure source
AlphaFold + ColabFold
GO
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0001046 Binding to a sequence of DNA that is part of a core promoter region. The core promoter is composed of the transcription start site and binding sites for the RNA polymerase and the basal transcription machinery. The transcribed region might be described as a gene, cistron, or operon.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
93.97

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.725
Structure A0A6A8EJH0
Pocket Pocket 3
P2Rank
Structure A0A6A8EJH0
Pocket No pockets
ColabFold model
FPocket 0.479 · Pocket 3
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 20 / 4744 genomes with a hit
Normalized 0.004

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0001046 Binding to a sequence of DNA that is part of a core promoter region. The core promoter is composed of the transcription start site and binding sites for the RNA polymerase and the basal transcription machinery. The transcribed region might be described as a gene, cistron, or operon.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
65 115 Pfam PF01381 Helix-turn-helix
65 115 InterPro IPR001387 Cro/C1-type helix-turn-helix domain
61 118 SUPERFAMILY SSF47413 lambda repressor-like DNA-binding domains
61 118 InterPro IPR010982 Lambda repressor-like, DNA-binding domain superfamily
46 120 Gene3D G3DSA:1.10.260.40 -
46 120 InterPro IPR010982 Lambda repressor-like, DNA-binding domain superfamily
7 118 PANTHER PTHR40455 ANTITOXIN HIGA
7 118 InterPro IPR039060 Antitoxin HigA
63 117 SMART SM00530 mbf_short4
63 117 InterPro IPR001387 Cro/C1-type helix-turn-helix domain
62 117 CDD cd00093 HTH_XRE
62 117 InterPro IPR001387 Cro/C1-type helix-turn-helix domain
64 117 ProSiteProfiles PS50943 Cro/C1-type HTH domain profile.
64 117 InterPro IPR001387 Cro/C1-type helix-turn-helix domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A6A8EJH0
AlphaFold — — full sequence — Viewing
ColabFold KP13_03493
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.725