Protein profile

KP13_03496

putative MFS general substrate transporter

Genome: KpKP13

Gene: AHE45872.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GP88
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Amino acids 390
Annotations 2
Features 48
PDB binders 0
Druggability 0.919

Overview

Basic information about this protein and its source genome.

Accession
KP13_03496
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45872.1
Status
annotated
Amino acids
390
Structure source
AlphaFold + ColabFold
GO
GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
87.77

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.919
Structure A0A0H3GP88
Pocket Pocket 7
P2Rank 0.943
Structure A0A0H3GP88
Pocket Pocket 1
ColabFold model
FPocket 0.933 · Pocket 5
P2Rank 0.948 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 12 / 4744 genomes with a hit
Normalized 0.003

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

48 records
Show feature table
Start End DB Term Name
114 137 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 22 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
38 322 Pfam PF07690 Major Facilitator Superfamily
38 322 InterPro IPR011701 Major facilitator superfamily
89 108 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 45 Phobius SIGNAL_PEPTIDE Signal peptide region
195 214 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
327 337 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
338 360 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
109 113 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
148 170 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
34 45 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
23 45 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
138 143 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
8 382 SUPERFAMILY SSF103473 MFS general substrate transporter
8 382 InterPro IPR036259 MFS transporter superfamily
82 87 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
175 197 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
174 194 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
388 390 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
60 82 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
236 246 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
366 387 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
270 280 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
24 383 PANTHER PTHR43124 PURINE EFFLUX PUMP PBUE
361 365 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
61 81 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
18 201 Gene3D G3DSA:1.20.1250.20 MFS general substrate transporter like domains
18 201 InterPro IPR036259 MFS transporter superfamily
278 300 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
113 135 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
300 304 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
88 108 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
169 173 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
305 326 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
217 239 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
215 235 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
249 271 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
247 269 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
305 327 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
213 387 Gene3D G3DSA:1.20.1250.20 MFS general substrate transporter like domains
213 387 InterPro IPR036259 MFS transporter superfamily
281 299 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
46 60 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
334 356 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
366 388 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
23 33 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
144 168 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GP88
AlphaFold — — full sequence — Viewing
ColabFold KP13_03496
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
7 0.919
1 0.844
6 0.268

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 30.43 0.934
2 3.33 0.118
3 3.17 0.108
4 2.63 0.077
5 2.56 0.073