Protein profile

KP13_03498

Anaerobic sulfatase-maturating enzyme

Genome: KpKP13

Gene: atsB AHE45874.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GTD2
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Amino acids 395
Annotations 5
Features 21
PDB binders 0
Druggability 0.347

Overview

Basic information about this protein and its source genome.

Accession
KP13_03498
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
atsB AHE45874.1
Status
annotated
Amino acids
395
Structure source
AlphaFold + ColabFold
GO
GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0051539 Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0051536 Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms. GO:0046872 Binding to a metal ion.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
92.31

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.347
Structure A0A0H3GTD2
Pocket Pocket 2
P2Rank 0.985
Structure A0A0H3GTD2
Pocket Pocket 1
ColabFold model
FPocket 0.982 · Pocket 2
P2Rank 0.921 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 10 / 4744 genomes with a hit
Normalized 0.002

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
  • GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
  • GO:0051539 Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
  • GO:0051536 Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms.
  • GO:0046872 Binding to a metal ion.

Sequence Features

Domain/signature hits from InterPro and related databases.

21 records
Show feature table
Start End DB Term Name
25 371 NCBIfam TIGR03942 anaerobic sulfatase maturase
22 377 Gene3D G3DSA:3.20.20.70 Aldolase class I
22 377 InterPro IPR013785 Aldolase-type TIM barrel
30 216 CDD cd01335 Radical_SAM
276 351 NCBIfam TIGR04085 SPASM domain
276 351 InterPro IPR023885 4Fe4S-binding SPASM domain
18 249 ProSiteProfiles PS51918 Radical SAM core domain profile.
18 249 InterPro IPR007197 Radical SAM
31 197 Pfam PF04055 Radical SAM superfamily
31 197 InterPro IPR007197 Radical SAM
20 378 SFLD SFLDF00285 anaerobic Ser-type sulfatase-maturating enzyme
20 378 InterPro IPR034491 Anaerobic Ser-type sulfatase-maturating enzyme
34 351 SFLD SFLDG01384 thioether bond formation requiring two auxiliary iron-sulfur clusters
34 351 InterPro IPR023867 Anaerobic sulphatase maturase, radical SAM
20 378 SFLD SFLDS00029 Radical SAM
20 378 InterPro IPR007197 Radical SAM
23 344 SUPERFAMILY SSF102114 Radical SAM enzymes
269 368 CDD cd21120 SPASM_anSME
269 368 InterPro IPR047207 Anaerobic sulfatase maturating enzyme, SPASM domain
11 381 PANTHER PTHR43273 ANAEROBIC SULFATASE-MATURATING ENZYME HOMOLOG ASLB-RELATED
11 381 InterPro IPR023867 Anaerobic sulphatase maturase, radical SAM

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GTD2
AlphaFold — — full sequence — Viewing
ColabFold KP13_03498
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.347
20 0.239

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 21.32 0.868
2 21.01 0.864
3 3.1 0.104