Protein profile

KP13_03509

putative periplasmic binding protein

Genome: KpKP13

Gene: AHE45886.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GPG2
Export view
Amino acids 372
Annotations 0
Features 15
PDB binders 0
Druggability 0.457

Overview

Basic information about this protein and its source genome.

Accession
KP13_03509
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45886.1
Status
annotated
Amino acids
372
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
92.91

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.457
Structure A0A0H3GPG2
Pocket Pocket 1
P2Rank 0.696
Structure A0A0H3GPG2
Pocket Pocket 1
ColabFold model
FPocket 0.395 · Pocket 1
P2Rank 0.548 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 36 / 4744 genomes with a hit
Normalized 0.008

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

15 records
Show feature table
Start End DB Term Name
1 7 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1 23 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
174 365 Gene3D G3DSA:3.40.50.1980 Nitrogenase molybdenum iron protein domain
101 313 Pfam PF01497 Periplasmic binding protein
101 313 InterPro IPR002491 ABC transporter periplasmic binding domain
1 23 Phobius SIGNAL_PEPTIDE Signal peptide region
20 23 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
24 372 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 23 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
31 360 SUPERFAMILY SSF53807 Helical backbone metal receptor
46 343 ProSiteProfiles PS50983 Iron siderophore/cobalamin periplasmic-binding domain profile.
46 343 InterPro IPR002491 ABC transporter periplasmic binding domain
7 360 PANTHER PTHR30535 VITAMIN B12-BINDING PROTEIN
8 19 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
22 172 Gene3D G3DSA:3.40.50.1980 Nitrogenase molybdenum iron protein domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GPG2
AlphaFold — — full sequence — Viewing
ColabFold KP13_03509
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.457

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 7.46 0.391
2 6.68 0.339
3 2.75 0.084
4 1.56 0.024