Protein profile

KP13_03512

Secretion protein HlyD family

Genome: KpKP13

Gene: AHE45889.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GTB6
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Amino acids 380
Annotations 0
Features 18
PDB binders 0
Druggability 0.882

Overview

Basic information about this protein and its source genome.

Accession
KP13_03512
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45889.1
Status
annotated
Amino acids
380
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
89.85

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.882
Structure A0A0H3GTB6
Pocket Pocket 1
P2Rank 0.043
Structure A0A0H3GTB6
Pocket Pocket 1
ColabFold model
FPocket 0.989 · Pocket 1
P2Rank 0.035 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 11 / 4744 genomes with a hit
Normalized 0.002

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

18 records
Show feature table
Start End DB Term Name
1 5 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
103 144 Coils Coil Coil
5 24 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
6 17 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
31 372 PANTHER PTHR30386 MEMBRANE FUSION SUBUNIT OF EMRAB-TOLC MULTIDRUG EFFLUX PUMP
1 21 Phobius SIGNAL_PEPTIDE Signal peptide region
62 96 Gene3D G3DSA:2.40.50.100 -
31 53 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
31 51 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
247 358 Gene3D G3DSA:2.40.30.170 -
97 115 Gene3D G3DSA:1.10.287.470 Helix hairpin bin
120 190 Gene3D G3DSA:1.10.287.470 Helix hairpin bin
18 21 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
52 380 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
63 111 Pfam PF13533 Biotin-lipoyl like
63 111 InterPro IPR039562 Membrane fusion protein, biotin-lipoyl like domain
60 115 SUPERFAMILY SSF111369 HlyD-like secretion proteins
22 30 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GTB6
AlphaFold — — full sequence — Viewing
ColabFold KP13_03512
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.882
7 0.344

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.24 0.055
2 1.26 0.012