Protein profile

KP13_03520

Sucrose operon repressor

Genome: KpKP13

Gene: scrR AHE45896.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GP58
Export view
Amino acids 349
Annotations 6
Features 27
PDB binders 5
Druggability 0.935

Overview

Basic information about this protein and its source genome.

Accession
KP13_03520
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
scrR AHE45896.1
Status
annotated
Amino acids
349
Structure source
AlphaFold + ColabFold
GO
GO:0009750 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fructose stimulus. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976 Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
91.3

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.935
Structure A0A0H3GP58
Pocket Pocket 1
P2Rank 0.652
Structure A0A0H3GP58
Pocket Pocket 1
ColabFold model
FPocket 0.489 · Pocket 3
P2Rank 0.522 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 64 / 4744 genomes with a hit
Normalized 0.013

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6
  • GO:0009750 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fructose stimulus.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
  • GO:0000976 Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

27 records
Show feature table
Start End DB Term Name
21 78 ProSiteProfiles PS50932 LacI-type HTH domain profile.
21 78 InterPro IPR000843 LacI-type HTH domain
83 345 CDD cd06274 PBP1_FruR
80 344 SUPERFAMILY SSF53822 Periplasmic binding protein-like I
80 344 InterPro IPR028082 Periplasmic binding protein-like I
24 77 CDD cd01392 HTH_LacI
24 77 InterPro IPR000843 LacI-type HTH domain
21 82 Gene3D G3DSA:1.10.260.40 -
21 82 InterPro IPR010982 Lambda repressor-like, DNA-binding domain superfamily
22 348 NCBIfam TIGR02417 D-fructose-responsive transcription factor
22 348 InterPro IPR012781 D-fructose-responsive transcription factor
32 42 PRINTS PR00036 LacI bacterial regulatory protein HTH signature
32 42 InterPro IPR000843 LacI-type HTH domain
22 32 PRINTS PR00036 LacI bacterial regulatory protein HTH signature
22 32 InterPro IPR000843 LacI-type HTH domain
21 78 SUPERFAMILY SSF47413 lambda repressor-like DNA-binding domains
21 78 InterPro IPR010982 Lambda repressor-like, DNA-binding domain superfamily
22 70 Pfam PF00356 Bacterial regulatory proteins, lacI family
22 70 InterPro IPR000843 LacI-type HTH domain
23 41 ProSitePatterns PS00356 LacI-type HTH domain signature.
20 93 SMART SM00354 laci3
20 93 InterPro IPR000843 LacI-type HTH domain
83 169 Gene3D G3DSA:3.40.50.2300 -
16 348 PANTHER PTHR30146 LACI-RELATED TRANSCRIPTIONAL REPRESSOR
174 348 Gene3D G3DSA:3.40.50.2300 -
84 331 Pfam PF13407 Periplasmic binding protein domain
84 331 InterPro IPR025997 Periplasmic binding protein

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GP58
AlphaFold — — full sequence — Viewing
ColabFold KP13_03520
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.935
3 0.325

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 9.09 0.487
2 1.93 0.039
3 1.29 0.014

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

28 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
171
1SXG
P46828 201.2 Da LogP 0.99 TPSA 66.4 ✓ Ro5 ✓ Clean c1ccc(cc1)NCCS(=O)(=O)O
6MP
2PUA
P0ACP7 134.1 Da LogP 0.66 TPSA 54.5 ✓ Ro5 ✓ Clean Cc1c2c(nc[nH]2)ncn1
ADE
2PUB
P0ACP7 135.1 Da LogP -0.06 TPSA 80.5 ✓ Ro5 ✓ Clean c1[nH]c2c(n1)c(ncn2)N
GUN
1WET
P0ACP7 151.1 Da LogP -0.77 TPSA 100.5 ✓ Ro5 ✓ Clean c1[nH]c2c(n1)C(=O)NC(=N2)N
HPA
1BDH
P0ACP7 136.1 Da LogP -0.35 TPSA 74.4 ✓ Ro5 ✓ Clean c1[nH]c2c(n1)N=CNC2=O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.