Protein profile

KP13_03525

Transcriptional regulator, LacI family

Genome: KpKP13

Gene: AHE45901.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GJK4
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Amino acids 344
Annotations 5
Features 24
PDB binders 0
Druggability 0.853

Overview

Basic information about this protein and its source genome.

Accession
KP13_03525
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45901.1
Status
annotated
Amino acids
344
Structure source
AlphaFold + ColabFold
GO
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976 Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
92.21

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.853
Structure A0A0H3GJK4
Pocket Pocket 1
P2Rank 0.876
Structure A0A0H3GJK4
Pocket Pocket 1
ColabFold model
FPocket 0.835 · Pocket 1
P2Rank 0.881 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 15 / 4744 genomes with a hit
Normalized 0.003

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
  • GO:0000976 Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

24 records
Show feature table
Start End DB Term Name
9 15 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
7 51 SUPERFAMILY SSF47413 lambda repressor-like DNA-binding domains
7 51 InterPro IPR010982 Lambda repressor-like, DNA-binding domain superfamily
8 61 SMART SM00354 laci3
8 61 InterPro IPR000843 LacI-type HTH domain
14 51 CDD cd01392 HTH_LacI
14 51 InterPro IPR000843 LacI-type HTH domain
63 326 SUPERFAMILY SSF53822 Periplasmic binding protein-like I
63 326 InterPro IPR028082 Periplasmic binding protein-like I
1 8 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1 23 Phobius SIGNAL_PEPTIDE Signal peptide region
9 49 ProSiteProfiles PS50932 LacI-type HTH domain profile.
9 49 InterPro IPR000843 LacI-type HTH domain
3 51 Gene3D G3DSA:1.10.260.40 -
3 51 InterPro IPR010982 Lambda repressor-like, DNA-binding domain superfamily
67 320 Pfam PF13407 Periplasmic binding protein domain
67 320 InterPro IPR025997 Periplasmic binding protein
167 304 Gene3D G3DSA:3.40.50.2300 -
24 344 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
16 23 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
70 320 Gene3D G3DSA:3.40.50.2300 -
63 328 PANTHER PTHR46847 D-ALLOSE-BINDING PERIPLASMIC PROTEIN-RELATED
66 338 CDD cd06307 PBP1_sugar_binding
14 51 Pfam PF00356 Bacterial regulatory proteins, lacI family

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GJK4
AlphaFold — — full sequence — Viewing
ColabFold KP13_03525
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.853

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 13.02 0.671
2 3.59 0.134
3 1.86 0.037
4 1.8 0.034