Protein profile

KP13_03527

transposase for insertion sequence element ISKpn1

Genome: KpKP13

Gene: AHE45903.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GL08
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Amino acids 173
Annotations 1
Features 11
PDB binders 0
Druggability 0.623

Overview

Basic information about this protein and its source genome.

Accession
KP13_03527
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45903.1
Status
annotated
Amino acids
173
Structure source
AlphaFold + ColabFold
GO
GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
85.76

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.623
Structure A0A0H3GL08
Pocket Pocket 1
P2Rank 0.186
Structure A0A0H3GL08
Pocket Pocket 1
ColabFold model
FPocket 0.476 · Pocket 1
P2Rank 0.214 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 5 / 4744 genomes with a hit
Normalized 0.001

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
1 54 SUPERFAMILY SSF46689 Homeodomain-like
1 54 InterPro IPR009057 Homeobox-like domain superfamily
39 120 SUPERFAMILY SSF48295 TrpR-like
39 120 InterPro IPR010921 Trp repressor/replication initiator
60 120 Gene3D G3DSA:1.10.10.10 -
60 120 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
2 59 Gene3D G3DSA:1.10.10.10 -
2 59 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
4 169 PANTHER PTHR33795 INSERTION ELEMENT IS150 PROTEIN INSJ
11 56 Pfam PF13518 Helix-turn-helix domain
65 118 Pfam PF13518 Helix-turn-helix domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GL08
AlphaFold — — full sequence — Viewing
ColabFold KP13_03527
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.038
2 0.002
8 0.001
10 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 4.98 0.186
2 2.35 0.05