Protein profile

KP13_03572

Transcriptional activator cadC

Genome: KpKP13

Gene: cadC AHE45914.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GJJ5
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Amino acids 522
Annotations 4
Features 23
PDB binders 0
Druggability 0.803

Overview

Basic information about this protein and its source genome.

Accession
KP13_03572
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
cadC AHE45914.1
Status
annotated
Amino acids
522
Structure source
AlphaFold + ColabFold
GO
GO:0005515 Binding to a protein. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0000160 A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
66.095
DEG E-value
0.0
Localization
Unknown
ColabFold pLDDT
83.92

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.803
Structure A0A0H3GJJ5
Pocket Pocket 2
P2Rank 0.848
Structure A0A0H3GJJ5
Pocket Pocket 1
ColabFold model
FPocket 0.637 · Pocket 1
P2Rank 0.856 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 30 / 4744 genomes with a hit
Normalized 0.006

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0005515 Binding to a protein.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0000160 A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

23 records
Show feature table
Start End DB Term Name
202 333 Pfam PF18500 CadC C-terminal domain 1
202 333 InterPro IPR040970 CadC C-terminal domain 1
170 192 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
3 102 ProSiteProfiles PS51755 OmpR/PhoB-type DNA-binding domain profile.
3 102 InterPro IPR001867 OmpR/PhoB-type DNA-binding domain
116 161 MobiDBLite mobidb-lite consensus disorder prediction
11 100 CDD cd00383 trans_reg_C
11 100 InterPro IPR001867 OmpR/PhoB-type DNA-binding domain
1 169 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
24 100 Pfam PF00486 Transcriptional regulatory protein, C terminal
24 100 InterPro IPR001867 OmpR/PhoB-type DNA-binding domain
193 522 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
4 102 SUPERFAMILY SSF46894 C-terminal effector domain of the bipartite response regulators
4 102 InterPro IPR016032 Signal transduction response regulator, C-terminal effector
201 360 Gene3D G3DSA:3.40.50.11830 -
24 100 SMART SM00862 Trans_reg_C_3
170 192 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
361 522 Gene3D G3DSA:1.25.40.10 Tetratricopeptide repeat domain
361 522 InterPro IPR011990 Tetratricopeptide-like helical domain superfamily
344 495 SUPERFAMILY SSF48452 TPR-like
344 495 InterPro IPR011990 Tetratricopeptide-like helical domain superfamily
2 105 Gene3D G3DSA:1.10.10.10 -
2 105 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GJJ5
AlphaFold — — full sequence — Viewing
ColabFold KP13_03572
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.803
35 0.448
19 0.251
38 0.213

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 12.74 0.66
2 3.38 0.121
3 1.31 0.014
4 1.11 0.008
5 0.96 0.005