Protein profile

KP13_03578

Outer membrane usher protein

Genome: KpKP13

Gene: AHE45921.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GJJ0
Export view
Amino acids 811
Annotations 5
Features 24
PDB binders 0
Druggability 0.473

Overview

Basic information about this protein and its source genome.

Accession
KP13_03578
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45921.1
Status
annotated
Amino acids
811
Structure source
AlphaFold + ColabFold
GO
GO:0005515 Binding to a protein. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015473 A porin that acts in the assembly of fimbria together with fimbrial chaperone. GO:0009297 The assembly from its constituent parts of a pilus, a short filamentous structure of bacterial cell, flagella-like in structure and generally present in many copies. Pili are variously involved in transfer of nucleic acids, adherence to surfaces, and formation of pellicles. Is required for bacterial conjugation, or can play a role in adherence to surfaces (when it is called a fimbrium), and in the formation of pellicles. GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
OuterMembrane
ColabFold pLDDT
86.17

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.473
Structure A0A0H3GJJ0
Pocket Pocket 29
P2Rank 0.421
Structure A0A0H3GJJ0
Pocket Pocket 1
ColabFold model
FPocket 0.955 · Pocket 3
P2Rank 0.4 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 3 / 4744 genomes with a hit
Normalized 0.001

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0005515 Binding to a protein.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0015473 A porin that acts in the assembly of fimbria together with fimbrial chaperone.
  • GO:0009297 The assembly from its constituent parts of a pilus, a short filamentous structure of bacterial cell, flagella-like in structure and generally present in many copies. Pili are variously involved in transfer of nucleic acids, adherence to surfaces, and formation of pellicles. Is required for bacterial conjugation, or can play a role in adherence to surfaces (when it is called a fimbrium), and in the formation of pellicles.
  • GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.

Sequence Features

Domain/signature hits from InterPro and related databases.

24 records
Show feature table
Start End DB Term Name
1 21 SignalP_EUK SignalP-noTM SignalP-noTM
8 16 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 7 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
245 334 FunFam G3DSA:2.60.40.3110:FF:000001 Putative fimbrial outer membrane usher
27 161 Pfam PF13954 PapC N-terminal domain
27 161 InterPro IPR025885 PapC, N-terminal domain
245 334 Gene3D G3DSA:2.60.40.3110 -
17 21 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
25 139 Gene3D G3DSA:3.10.20.410 -
25 139 InterPro IPR037224 PapC, N-terminal domain superfamily
10 804 PANTHER PTHR30451 OUTER MEMBRANE USHER PROTEIN
10 804 InterPro IPR000015 Outer membrane usher protein
721 804 Gene3D G3DSA:2.60.40.2070 -
721 804 InterPro IPR043142 PapC-like, C-terminal domain superfamily
726 787 Pfam PF13953 PapC C-terminal domain
726 787 InterPro IPR025949 PapC-like, C-terminal domain
25 139 SUPERFAMILY SSF141729 FimD N-terminal domain-like
1 21 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
1 21 Phobius SIGNAL_PEPTIDE Signal peptide region
178 715 Pfam PF00577 Outer membrane usher protein
178 715 InterPro IPR000015 Outer membrane usher protein
630 720 Gene3D G3DSA:2.60.40.2610 Outer membrane usher protein FimD, plug domain
630 720 InterPro IPR042186 Outer membrane usher protein FimD, plug domain
22 811 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GJJ0
AlphaFold — — full sequence — Viewing
ColabFold KP13_03578
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.001
30 0.001
16 0.0
61 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 9.18 0.421
2 8.07 0.363
3 2.73 0.067
4 2.22 0.044
5 1.76 0.027