Protein profile

KP13_03615

Inosine-guanosine kinase

Genome: KpKP13

Gene: gsk AHE45957.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GP56
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Amino acids 434
Annotations 8
Features 14
PDB binders 1
Druggability 0.71

Overview

Basic information about this protein and its source genome.

Accession
KP13_03615
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
gsk AHE45957.1
Status
annotated
Amino acids
434
Structure source
AlphaFold + ColabFold
EC
2.7.1.73
GO
GO:0008906 Catalysis of the reaction: ATP + inosine = ADP + IMP. GO:0016301 Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. GO:0006166 Any process which produces a purine nucleoside from derivatives of it, without de novo synthesis. GO:0106366 Catalysis of the reaction: ATP + guanosine = ADP + GMP. GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0032263 Any process which produces guanosine monophosphate from derivatives of it, without de novo synthesis.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
94.09

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.71
Structure A0A0H3GP56
Pocket Pocket 29
P2Rank 0.982
Structure A0A0H3GP56
Pocket Pocket 1
ColabFold model
FPocket 0.703 · Pocket 1
P2Rank 0.97 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 123 / 4744 genomes with a hit
Normalized 0.026

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 7 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

7
  • GO:0008906 Catalysis of the reaction: ATP + inosine = ADP + IMP.
  • GO:0016301 Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
  • GO:0006166 Any process which produces a purine nucleoside from derivatives of it, without de novo synthesis.
  • GO:0106366 Catalysis of the reaction: ATP + guanosine = ADP + GMP.
  • GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
  • GO:0032263 Any process which produces guanosine monophosphate from derivatives of it, without de novo synthesis.
  • GO:0032264 Any process which produces inosine monophosphate from derivatives of it, without de novo synthesis.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
1 434 Hamap MF_02246 Guanosine-inosine kinase [gsk].
1 434 InterPro IPR046405 Guanosine-inosine kinase
352 365 ProSitePatterns PS00584 pfkB family of carbohydrate kinases signature 2.
352 365 InterPro IPR002173 Carbohydrate/purine kinase, PfkB, conserved site
36 416 SUPERFAMILY SSF53613 Ribokinase-like
36 416 InterPro IPR029056 Ribokinase-like
146 296 Pfam PF00294 pfkB family carbohydrate kinase
146 296 InterPro IPR011611 Carbohydrate kinase PfkB
179 197 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 178 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
198 434 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
35 417 Gene3D G3DSA:3.40.1190.20 -
35 417 InterPro IPR029056 Ribokinase-like
34 299 PANTHER PTHR43320 SUGAR KINASE

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GP56
AlphaFold — — full sequence — Viewing
ColabFold KP13_03615
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
29 0.71
1 0.644

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 34.27 0.949
2 4.77 0.211
3 1.88 0.037
4 0.99 0.005
5 0.74 0.002

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

51 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
G4P
6VWP
P0AEW6 603.2 Da LogP -2.22 TPSA 345.6 3 viol. ✓ Clean c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O…

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.