Protein profile

KP13_03619

Recombination protein recR

Genome: KpKP13

Gene: AHE45961.1 recR Structure source: AlphaFold + ColabFold UniProt A0A0H3GKL4
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Amino acids 201
Annotations 5
Features 24
PDB binders 0
Druggability 0.969

Overview

Basic information about this protein and its source genome.

Accession
KP13_03619
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45961.1 recR
Status
annotated
Amino acids
201
Structure source
AlphaFold + ColabFold
GO
GO:0006310 Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0046872 Binding to a metal ion. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006281 The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. GO:0008270 Binding to a zinc ion (Zn).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
43.814
DEG E-value
1.45e-50
Localization
Cytoplasmic
ColabFold pLDDT
95.63

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.969
Structure A0A0H3GKL4
Pocket Pocket 2
P2Rank 0.047
Structure A0A0H3GKL4
Pocket Pocket 1
ColabFold model
FPocket 0.641 · Pocket 16
P2Rank 0.042 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 200 / 4744 genomes with a hit
Normalized 0.042

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0006310 Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
  • GO:0046872 Binding to a metal ion.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0006281 The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
  • GO:0008270 Binding to a zinc ion (Zn).

Sequence Features

Domain/signature hits from InterPro and related databases.

24 records
Show feature table
Start End DB Term Name
81 166 SMART SM00493 toprim5
81 166 InterPro IPR006171 TOPRIM domain
2 199 SUPERFAMILY SSF111304 Recombination protein RecR
2 199 InterPro IPR023627 Recombination protein RecR
81 176 ProSiteProfiles PS50880 Toprim domain profile.
81 176 InterPro IPR006171 TOPRIM domain
81 192 CDD cd01025 TOPRIM_recR
81 192 InterPro IPR034137 RecR, TOPRIM domain
2 197 NCBIfam TIGR00615 recombination mediator RecR
2 197 InterPro IPR000093 DNA recombination protein RecR
41 77 Pfam PF02132 RecR protein
41 77 InterPro IPR023628 Recombination protein RecR, C4-type zinc finger
172 199 Gene3D G3DSA:6.10.250.240 -
1 51 FunFam G3DSA:1.10.8.420:FF:000001 Recombination protein RecR
1 199 Hamap MF_00017 Recombination protein RecR [recR].
1 199 InterPro IPR000093 DNA recombination protein RecR
1 199 PANTHER PTHR30446 RECOMBINATION PROTEIN RECR
77 171 Gene3D G3DSA:3.40.1360.10 -
81 172 Pfam PF13662 Toprim domain
81 172 InterPro IPR006171 TOPRIM domain
77 171 FunFam G3DSA:3.40.1360.10:FF:000001 Recombination protein RecR
57 78 ProSitePatterns PS01300 RecR protein signature.
57 78 InterPro IPR015967 Recombination protein RecR, conserved site
1 51 Gene3D G3DSA:1.10.8.420 RecR Domain 1

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GKL4
AlphaFold — — full sequence — Viewing
ColabFold KP13_03619
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.969

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.06 0.046