Protein profile

KP13_03620

nucleoid-associated protein

Genome: KpKP13

Gene: AHE45962.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GP51
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Amino acids 110
Annotations 3
Features 16
PDB binders 0
Druggability 0.328

Overview

Basic information about this protein and its source genome.

Accession
KP13_03620
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45962.1
Status
annotated
Amino acids
110
Structure source
AlphaFold + ColabFold
GO
GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0043590 The region of a bacterial cell to which the DNA is confined. GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
82.727
DEG E-value
2.65e-64
Localization
Unknown
ColabFold pLDDT
86.9

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.328
Structure A0A0H3GP51
Pocket Pocket 5
P2Rank 0.002
Structure A0A0H3GP51
Pocket Pocket 1
ColabFold model
FPocket 0.557 · Pocket 2
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 222 / 4744 genomes with a hit
Normalized 0.047

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0043590 The region of a bacterial cell to which the DNA is confined.
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records
Show feature table
Start End DB Term Name
6 99 Hamap MF_00274 Nucleoid-associated protein YbaB [ybaB].
6 99 InterPro IPR004401 Nucleoid-associated protein YbaB/EbfC
1 110 FunFam G3DSA:3.30.1310.10:FF:000001 Nucleoid-associated protein YbaB
12 100 Pfam PF02575 YbaB/EbfC DNA-binding family
12 100 InterPro IPR004401 Nucleoid-associated protein YbaB/EbfC
6 106 PANTHER PTHR33449 NUCLEOID-ASSOCIATED PROTEIN YBAB
6 106 InterPro IPR004401 Nucleoid-associated protein YbaB/EbfC
2 106 NCBIfam TIGR00103 YbaB/EbfC family nucleoid-associated protein
2 106 InterPro IPR004401 Nucleoid-associated protein YbaB/EbfC
12 104 SUPERFAMILY SSF82607 YbaB-like
12 104 InterPro IPR036894 Nucleoid-associated protein YbaB-like domain superfamily
8 35 Coils Coil Coil
4 110 PIRSF PIRSF004555 UCP004555
4 110 InterPro IPR004401 Nucleoid-associated protein YbaB/EbfC
2 110 Gene3D G3DSA:3.30.1310.10 -
2 110 InterPro IPR036894 Nucleoid-associated protein YbaB-like domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GP51
AlphaFold — — full sequence — Viewing
ColabFold KP13_03620
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
5 0.328