Protein profile

KP13_03629

Acriflavine resistance protein A

Genome: KpKP13

Gene: AHE45971.1 acrA Structure source: AlphaFold + ColabFold UniProt A0A0H3GP47
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Amino acids 397
Annotations 7
Features 25
PDB binders 0
Druggability 0.448

Overview

Basic information about this protein and its source genome.

Accession
KP13_03629
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45971.1 acrA
Status
annotated
Amino acids
397
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015721 The directed movement of bile acid and bile salts into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0046677 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
85.279
DEG E-value
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
85.48

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.448
Structure A0A0H3GP47
Pocket Pocket 15
P2Rank 0.002
Structure A0A0H3GP47
Pocket Pocket 1
ColabFold model
FPocket 0.785 · Pocket 5
P2Rank 0.151 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 147 / 4744 genomes with a hit
Normalized 0.031

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

7 GO

Gene Ontology (GO)

7
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0015721 The directed movement of bile acid and bile salts into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
  • GO:0046677 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.
  • GO:0140330 A process that reduces or removes the toxicity of a xenobiotic by exporting it outside the cell through the outer membrane.

Sequence Features

Domain/signature hits from InterPro and related databases.

25 records
Show feature table
Start End DB Term Name
52 300 SUPERFAMILY SSF111369 HlyD-like secretion proteins
1 5 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
375 397 MobiDBLite mobidb-lite consensus disorder prediction
58 283 Gene3D G3DSA:2.40.30.170 -
63 293 Pfam PF16576 Barrel-sandwich domain of CusB or HlyD membrane-fusion
63 293 InterPro IPR032317 RND efflux pump, membrane fusion protein, barrel-sandwich domain
378 397 MobiDBLite mobidb-lite consensus disorder prediction
1 21 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
43 360 Pfam PF00529 Cation efflux system protein CusB domain 1
43 360 InterPro IPR043602 Cation efflux system protein CusB, domain 1
17 21 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
284 376 Gene3D G3DSA:2.40.420.20 -
99 172 Gene3D G3DSA:1.10.287.470 Helix hairpin bin
64 208 Gene3D G3DSA:2.40.50.100 -
1 21 Phobius SIGNAL_PEPTIDE Signal peptide region
284 376 FunFam G3DSA:2.40.420.20:FF:000001 Efflux RND transporter periplasmic adaptor subunit
40 375 NCBIfam TIGR01730 efflux RND transporter periplasmic adaptor subunit
40 375 InterPro IPR006143 RND efflux pump, membrane fusion protein
204 284 FunFam G3DSA:2.40.30.170:FF:000001 Multidrug resistance efflux transporter MdtE
6 16 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
99 172 FunFam G3DSA:1.10.287.470:FF:000002 Efflux RND transporter periplasmic adaptor subunit
1 25 ProSiteProfiles PS51257 Prokaryotic membrane lipoprotein lipid attachment site profile.
1 387 PANTHER PTHR30158 ACRA/E-RELATED COMPONENT OF DRUG EFFLUX TRANSPORTER
1 21 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
22 397 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GP47
AlphaFold — — full sequence — Viewing
ColabFold KP13_03629
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
15 0.448