Protein profile

KP13_32124

hemolysin expression-modulating protein Hha

Genome: KpKP13

Gene: hha AHE45975.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GSW0
Export view
Amino acids 72
Annotations 0
Features 7
PDB binders 0
Druggability 0.374

Overview

Basic information about this protein and its source genome.

Accession
KP13_32124
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
hha AHE45975.1
Status
annotated
Amino acids
72
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
97.222
DEG E-value
1.41e-48
Localization
Unknown
ColabFold pLDDT
91.84

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.374
Structure A0A0H3GSW0
Pocket Pocket 2
P2Rank
Structure A0A0H3GSW0
Pocket No pockets
ColabFold model
FPocket 0.39 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 105 / 4744 genomes with a hit
Normalized 0.022

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

7 records
Show feature table
Start End DB Term Name
2 72 SUPERFAMILY SSF68989 Hemolysin expression modulating protein HHA
2 72 InterPro IPR036666 HHA superfamily
1 72 Gene3D G3DSA:1.20.1280.40 HHA
1 72 InterPro IPR036666 HHA superfamily
1 72 FunFam G3DSA:1.20.1280.40:FF:000001 Hemolysin expression modulator Hha
13 69 Pfam PF05321 Haemolysin expression modulating protein
13 69 InterPro IPR007985 Haemolysin expression modulating, HHA

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GSW0
AlphaFold — — full sequence — Viewing
ColabFold KP13_32124
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.374