Protein profile

KP13_03634

Maltose O-acetyltransferase

Genome: KpKP13

Gene: AHE45976.1 maa Structure source: AlphaFold + ColabFold UniProt A0A0H3GKK7
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Amino acids 188
Annotations 4
Features 16
PDB binders 6
Druggability 0.123

Overview

Basic information about this protein and its source genome.

Accession
KP13_03634
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45976.1 maa
Status
annotated
Amino acids
188
Structure source
AlphaFold + ColabFold
GO
GO:0016407 Catalysis of the transfer of an acetyl group to an acceptor molecule. GO:0016740 Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0016413 Catalysis of the transfer of an acetyl group to an oxygen atom on the acceptor molecule.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
41.509
DEG E-value
9.91e-30
Localization
Cytoplasmic
ColabFold pLDDT
97.32

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.123
Structure A0A0H3GKK7
Pocket Pocket 6
P2Rank 0.078
Structure A0A0H3GKK7
Pocket Pocket 1
ColabFold model
FPocket 0.369 · Pocket 4
P2Rank 0.111 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 195 / 4744 genomes with a hit
Normalized 0.041

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0016407 Catalysis of the transfer of an acetyl group to an acceptor molecule.
  • GO:0016740 Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0016413 Catalysis of the transfer of an acetyl group to an oxygen atom on the acceptor molecule.

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records
Show feature table
Start End DB Term Name
92 109 Pfam PF14602 Hexapeptide repeat of succinyl-transferase
92 109 InterPro IPR001451 Hexapeptide repeat
129 164 Pfam PF14602 Hexapeptide repeat of succinyl-transferase
129 164 InterPro IPR001451 Hexapeptide repeat
2 183 SUPERFAMILY SSF51161 Trimeric LpxA-like enzymes
2 183 InterPro IPR011004 Trimeric LpxA-like superfamily
13 180 CDD cd03357 LbH_MAT_GAT
5 59 SMART SM01266 Mac_2
5 59 InterPro IPR024688 Maltose/galactoside acetyltransferase
7 58 Pfam PF12464 Maltose acetyltransferase
7 58 InterPro IPR024688 Maltose/galactoside acetyltransferase
138 166 ProSitePatterns PS00101 Hexapeptide-repeat containing-transferases signature.
138 166 InterPro IPR018357 Hexapeptide transferase, conserved site
1 183 Gene3D G3DSA:2.160.10.10 Hexapeptide repeat proteins
3 185 PANTHER PTHR23416 SIALIC ACID SYNTHASE-RELATED
1 184 FunFam G3DSA:2.160.10.10:FF:000008 Maltose O-acetyltransferase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GKK7
AlphaFold — — full sequence — Viewing
ColabFold KP13_03634
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.4 0.018

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

33 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
B2M
3DHO
P50870 453.1 Da LogP 5.08 TPSA 74.6 1 viol. Alert Cc1cc(c2cc(ccc2n1)Br)C(=O)N/N=C\c3cc(cc(c3O)Cl)…
DCA
2XAT
P26841 735.5 Da LogP -1.58 TPSA 346.6 3 viol. ✓ Clean CCNC(=O)CCNC(=O)[C@@H](C(C)(C)CO[P@@](=O)(O)O[P…
DOL
1MRL
P50870 690.9 Da LogP 2.27 TPSA 176.4 2 viol. ✓ Clean CCN(CC)CCS(=O)(=O)[C@@H]1CCN2[C@H]1C(=O)O[C@@H]…
PBM
1OCX
P77791 252.3 Da LogP 1.37 TPSA 0.0 ✓ Ro5 ✓ Clean C[Pb+](C)C
SOP
2WLG
Q93S40 823.6 Da LogP -1.27 TPSA 363.6 3 viol. ✓ Clean CC(=O)CSCCNC(=O)CCNC(=O)[C@@H](C(C)(C)CO[P@](=O…
SXA
6X3C
P26839 400.4 Da LogP -0.61 TPSA 162.3 ✓ Ro5 ✓ Clean CC(=O)SCCNC(=O)CCNC(=O)[C@H](C(C)(C)COP(=O)(O)O…

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.