Protein profile

KP13_32126

maltose-inducible porin maltoporin

Genome: KpKP13

Gene: AHE45982.1 lamB Structure source: AlphaFold + ColabFold UniProt A6T5L4
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Amino acids 434
Annotations 8
Features 18
PDB binders 0
Druggability 0.802

Overview

Basic information about this protein and its source genome.

Accession
KP13_32126
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45982.1 lamB
Status
annotated
Amino acids
434
Structure source
AlphaFold + ColabFold
GO
GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0042956 The directed movement of maltodextrin, any polysaccharide of glucose residues in beta-(1,4) linkage, across a membrane. GO:0034219 The process in which a carbohydrate is transported across a membrane. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015481 Enables the transfer of maltose from one side of a membrane to the other. Maltose is the disaccharide 4-O-alpha-D-glucopyranosyl-D-glucopyranose, an intermediate in the enzymatic breakdown of glycogen and starch. This transporter is a porin so enables the energy independent passage of substances, sized less than 1000 Da, across a membrane. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria. GO:0042958 Enables the transfer of maltodextrin, any polysaccharide of glucose residues in beta-(1,4) linkage, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
OuterMembrane
ColabFold pLDDT
91.48

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.802
Structure A6T5L4
Pocket Pocket 16
P2Rank 0.668
Structure A6T5L4
Pocket Pocket 1
ColabFold model
FPocket 0.532 · Pocket 9
P2Rank 0.451 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 24 / 4744 genomes with a hit
Normalized 0.005

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

8 GO

Gene Ontology (GO)

8
  • GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.
  • GO:0042956 The directed movement of maltodextrin, any polysaccharide of glucose residues in beta-(1,4) linkage, across a membrane.
  • GO:0034219 The process in which a carbohydrate is transported across a membrane.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0015481 Enables the transfer of maltose from one side of a membrane to the other. Maltose is the disaccharide 4-O-alpha-D-glucopyranosyl-D-glucopyranose, an intermediate in the enzymatic breakdown of glycogen and starch. This transporter is a porin so enables the energy independent passage of substances, sized less than 1000 Da, across a membrane. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria.
  • GO:0042958 Enables the transfer of maltodextrin, any polysaccharide of glucose residues in beta-(1,4) linkage, from one side of a membrane to the other.
  • GO:0015768 The directed movement of maltose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Maltose is the disaccharide 4-O-alpha-D-glucopyranosyl-D-glucopyranose, an intermediate in the catabolism of glycogen and starch.
  • GO:0015288 Enables the transfer of substances, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria.

Sequence Features

Domain/signature hits from InterPro and related databases.

18 records
Show feature table
Start End DB Term Name
12 434 PANTHER PTHR38762 CRYPTIC OUTER MEMBRANE PORIN BGLH-RELATED
44 434 Pfam PF02264 LamB porin
44 434 InterPro IPR003192 Porin, LamB-type
42 434 CDD cd01346 Maltoporin-like
42 434 InterPro IPR003192 Porin, LamB-type
1 17 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
18 29 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
42 434 SUPERFAMILY SSF56935 Porins
35 434 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 34 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
42 434 Gene3D G3DSA:2.40.170.10 Porin, LamB type
42 434 InterPro IPR036998 Porin, LamB-type superfamily
30 34 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
13 434 Hamap MF_01301 Maltoporin [lamB].
13 434 InterPro IPR023738 Maltoporin
1 34 Phobius SIGNAL_PEPTIDE Signal peptide region
1 34 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
20 42 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A6T5L4
AlphaFold — — full sequence — Viewing
ColabFold KP13_32126
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
16 0.802
15 0.498
2 0.375

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 7.91 0.42
2 2.44 0.066
3 2.39 0.063
4 2.06 0.046