Protein profile

KP13_03644

Arabinogalactan endo-1,4-beta-galactosidase

Genome: KpKP13

Gene: AHE45984.1 ganB Structure source: AlphaFold + ColabFold UniProt A0A0H3GNN0
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Amino acids 400
Annotations 4
Features 15
PDB binders 0
Druggability 0.461

Overview

Basic information about this protein and its source genome.

Accession
KP13_03644
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45984.1 ganB
Status
annotated
Amino acids
400
Structure source
AlphaFold + ColabFold
EC
3.2.1.89
GO
GO:0015926 Catalysis of the hydrolysis of glucosyl compounds, substances containing a group derived from a cyclic form of glucose or a glucose derivative. GO:0031218 Catalysis of the endohydrolysis of (1->4)-beta-D-galactosidic linkages in arabinogalactans. GO:0045490 The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
94.28

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.461
Structure A0A0H3GNN0
Pocket Pocket 2
P2Rank 0.904
Structure A0A0H3GNN0
Pocket Pocket 1
ColabFold model
FPocket 0.674 · Pocket 2
P2Rank 0.896 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 36 / 4744 genomes with a hit
Normalized 0.008

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 3 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

3
  • GO:0015926 Catalysis of the hydrolysis of glucosyl compounds, substances containing a group derived from a cyclic form of glucose or a glucose derivative.
  • GO:0031218 Catalysis of the endohydrolysis of (1->4)-beta-D-galactosidic linkages in arabinogalactans.
  • GO:0045490 The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues.

Sequence Features

Domain/signature hits from InterPro and related databases.

15 records
Show feature table
Start End DB Term Name
24 400 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
40 399 Pfam PF07745 Glycosyl hydrolase family 53
40 399 InterPro IPR011683 Glycosyl hydrolase family 53
15 399 SUPERFAMILY SSF51445 (Trans)glycosidases
15 399 InterPro IPR017853 Glycoside hydrolase superfamily
1 3 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1 23 Phobius SIGNAL_PEPTIDE Signal peptide region
18 400 Gene3D G3DSA:3.20.20.80 Glycosidases
17 400 PANTHER PTHR34983 ARABINOGALACTAN ENDO-BETA-1,4-GALACTANASE A
17 400 InterPro IPR011683 Glycosyl hydrolase family 53
7 29 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 23 SignalP_EUK SignalP-noTM SignalP-noTM
1 23 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
16 23 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
4 15 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GNN0
AlphaFold — — full sequence — Viewing
ColabFold KP13_03644
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.461

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 22.67 0.882
2 1.35 0.016