Protein profile

KP13_20430

extracellular solute-binding protein

Genome: KpKP13

Gene: ANJ86621.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GP24
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Amino acids 566
Annotations 2
Features 9
PDB binders 3
Druggability 0.794

Overview

Basic information about this protein and its source genome.

Accession
KP13_20430
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
ANJ86621.1
Status
annotated
Amino acids
566
Structure source
AlphaFold + ColabFold
GO
GO:1904680 Enables the transfer of a peptide from one side of a membrane to the other. GO:0015833 The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
87.8

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.794
Structure A0A0H3GP24
Pocket Pocket 6
P2Rank 0.952
Structure A0A0H3GP24
Pocket Pocket 1
ColabFold model
FPocket 0.998 · Pocket 1
P2Rank 0.802 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 71 / 4744 genomes with a hit
Normalized 0.015

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:1904680 Enables the transfer of a peptide from one side of a membrane to the other.
  • GO:0015833 The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
7 118 Pfam PF12793 Sugar transport-related sRNA regulator N-term
7 118 InterPro IPR025370 Transcriptional regulator SgrR, N-terminal HTH domain
122 561 SUPERFAMILY SSF53850 Periplasmic binding protein-like II
114 308 Gene3D G3DSA:3.40.190.10 -
126 561 PANTHER PTHR30290 PERIPLASMIC BINDING COMPONENT OF ABC TRANSPORTER
126 561 InterPro IPR039424 Solute-binding protein family 5
390 532 Gene3D G3DSA:3.10.105.10 -
166 303 Pfam PF00496 Bacterial extracellular solute-binding proteins, family 5 Middle
166 303 InterPro IPR000914 Solute-binding protein family 5 domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GP24
AlphaFold — — full sequence — Viewing
ColabFold KP13_20430
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
6 0.794

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 12.61 0.656
2 11.89 0.63
3 7.53 0.396
4 4.04 0.162
5 2.84 0.089

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

9 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
N72
6TFQ
O50271 309.3 Da LogP -3.46 TPSA 184.6 1 viol. ✓ Clean C(CC(=O)O)[C@H](C(=O)O)NCC(=O)[C@@H]([C@@H]([C@…
N7T
6TFS
O50271 309.3 Da LogP -3.46 TPSA 184.6 1 viol. ✓ Clean C(CC(=O)O)[C@@H](C(=O)O)NCC(=O)[C@H]([C@@H]([C@…
OXL
4OEV
Q0P844 88.0 Da LogP -3.51 TPSA 80.3 ✓ Ro5 ✓ Clean C(=O)(C(=O)[O-])[O-]

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.