Amino acids
432
Annotations
10
Features
32
PDB binders
0
Druggability
0.77
Overview
Basic information about this protein and its source genome.
- Accession
- KP13_03678
- Gene
- tig AHE46018.1
- Status
- annotated
- Amino acids
- 432
- Structure source
- AlphaFold + ColabFold
EC
GO
GO:0015031 The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
GO:0003755 Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).
GO:0006457 The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
GO:0044183 Binding to a protein or a protein-containing complex to assist the protein folding process.
GO:0043022 Binding to a ribosome.
Target profile
Computed evidence for target prioritization.
- Human off-target
- No hit
- Human identity (%)
- 0.0
- Gut microbiome off-target
- hit
- Essential (DEG)
- Y
- DEG identity (%)
- 50.704
- DEG E-value
- 1.32e-150
- Localization
- Cytoplasmic
- ColabFold pLDDT
- 92.06
Selected Druggability evidence
AlphaFold / UniProt modelSelected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.
FPocket
0.77
P2Rank
0.338
ColabFold model
Core conservation
Conserved core gene
Gut microbiome
152 / 4744
genomes with a hit
Sequence
Primary amino-acid sequence viewer.
Functional Annotations
Enzyme classification and Gene Ontology terms linked to this protein.
1 EC
9 GO
Enzyme Commission (EC)
1Gene Ontology (GO)
9- GO:0015031 The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
- GO:0003755 Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).
- GO:0006457 The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
- GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
- GO:0044183 Binding to a protein or a protein-containing complex to assist the protein folding process.
- GO:0043022 Binding to a ribosome.
- GO:0051083 The process of assisting in the correct noncovalent assembly of the ribosome-bound nascent chains of a multidomain protein whilst other parts of the protein are still being translated.
- GO:0051301 The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
- GO:0043335 The process of assisting in the disassembly of non-covalent linkages in a protein or protein aggregate, often where the proteins are in a non-functional or denatured state.
Sequence Features
Domain/signature hits from InterPro and related databases.
32 records
Show feature table
| Start | End | DB | Term | Name |
|---|---|---|---|---|
| 1 | 432 | PIRSF | PIRSF003095 | Trigger_factor |
| 1 | 432 | InterPro | IPR005215 | Trigger factor |
| 262 | 412 | Pfam | PF05698 | Bacterial trigger factor protein (TF) C-terminus |
| 262 | 412 | InterPro | IPR008880 | Trigger factor, C-terminal |
| 1 | 131 | SUPERFAMILY | SSF102735 | Trigger factor ribosome-binding domain |
| 1 | 131 | InterPro | IPR036611 | Trigger factor ribosome-binding domain superfamily |
| 248 | 429 | SUPERFAMILY | SSF109998 | Triger factor/SurA peptide-binding domain-like |
| 248 | 429 | InterPro | IPR027304 | Trigger factor/SurA domain superfamily |
| 150 | 246 | FunFam | G3DSA:3.10.50.40:FF:000001 | Trigger factor |
| 1 | 115 | Gene3D | G3DSA:3.30.70.1050 | - |
| 1 | 115 | InterPro | IPR036611 | Trigger factor ribosome-binding domain superfamily |
| 1 | 418 | Hamap | MF_00303 | Trigger factor [tig]. |
| 1 | 418 | InterPro | IPR005215 | Trigger factor |
| 116 | 417 | Gene3D | G3DSA:1.10.3120.10 | - |
| 116 | 417 | InterPro | IPR037041 | Trigger factor, C-terminal domain superfamily |
| 1 | 115 | FunFam | G3DSA:3.30.70.1050:FF:000001 | Trigger factor |
| 223 | 243 | Coils | Coil | Coil |
| 13 | 412 | NCBIfam | TIGR00115 | trigger factor |
| 13 | 412 | InterPro | IPR005215 | Trigger factor |
| 360 | 380 | Coils | Coil | Coil |
| 230 | 417 | FunFam | G3DSA:1.10.3120.10:FF:000001 | Trigger factor |
| 160 | 235 | Pfam | PF00254 | FKBP-type peptidyl-prolyl cis-trans isomerase |
| 160 | 235 | InterPro | IPR001179 | FKBP-type peptidyl-prolyl cis-trans isomerase domain |
| 96 | 241 | SUPERFAMILY | SSF54534 | FKBP-like |
| 161 | 249 | ProSiteProfiles | PS50059 | FKBP-type peptidyl-prolyl cis-trans isomerase domain profile. |
| 161 | 249 | InterPro | IPR001179 | FKBP-type peptidyl-prolyl cis-trans isomerase domain |
| 1 | 404 | PANTHER | PTHR30560 | TRIGGER FACTOR CHAPERONE AND PEPTIDYL-PROLYL CIS/TRANS ISOMERASE |
| 1 | 404 | InterPro | IPR005215 | Trigger factor |
| 150 | 246 | Gene3D | G3DSA:3.10.50.40 | - |
| 150 | 246 | InterPro | IPR046357 | Peptidyl-prolyl cis-trans isomerase domain superfamily |
| 1 | 143 | Pfam | PF05697 | Bacterial trigger factor protein (TF) |
| 1 | 143 | InterPro | IPR008881 | Trigger factor, ribosome-binding, bacterial |
3D Structure
Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.
Loading 3D structure...
Legend
High
Medium
Low
Structural evidence
0 + 2Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.
| Entry | Method | Resolution | Chain | Coverage | Links | Status |
|---|---|---|---|---|---|---|
|
AlphaFold
AF_A0A0H3GP17
|
AlphaFold | — | — | full sequence | — | Viewing |
|
ColabFold
KP13_03678
|
ColabFold | — | — | full sequence | — | Loaded |
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer
Pockets (FPOCKET)
Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).
| FPOCKET | Sticks | Spheres | Surfaces | Druggability | Labels | Zoom | Positions |
|---|---|---|---|---|---|---|---|
| 1 | 0.77 | ||||||
| 9 | 0.378 | ||||||
| 11 | 0.209 |
Pockets (P2RANK)
Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).
| P2RANK | Sticks | Spheres | Surfaces | Score | Probability | Labels | Zoom | Positions |
|---|---|---|---|---|---|---|---|---|
| 1 | 6.91 | 0.356 | ||||||
| 2 | 1.14 | 0.009 |
Pockets (FPOCKET)
Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).
| FPOCKET | Sticks | Spheres | Surfaces | Druggability | Labels | Zoom | Positions |
|---|---|---|---|---|---|---|---|
| 1 | 0.699 |
Pockets (P2RANK)
Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).
| P2RANK | Sticks | Spheres | Surfaces | Score | Probability | Labels | Zoom | Positions |
|---|---|---|---|---|---|---|---|---|
| 1 | 5.57 | 0.267 | ||||||
| 2 | 0.9 | 0.004 |