Protein profile

KP13_03695

Xylose isomerase-like TIM barrel

Genome: KpKP13

Gene: AHE46032.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GNI5
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Amino acids 272
Annotations 1
Features 11
PDB binders 0
Druggability 0.359

Overview

Basic information about this protein and its source genome.

Accession
KP13_03695
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46032.1
Status
annotated
Amino acids
272
Structure source
AlphaFold + ColabFold
GO
GO:0016853 Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
96.02

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.359
Structure A0A0H3GNI5
Pocket Pocket 13
P2Rank 0.535
Structure A0A0H3GNI5
Pocket Pocket 1
ColabFold model
FPocket 0.177 · Pocket 2
P2Rank 0.554 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 14 / 4744 genomes with a hit
Normalized 0.003

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0016853 Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
6 14 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 5 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1 25 Phobius SIGNAL_PEPTIDE Signal peptide region
22 252 Pfam PF01261 Xylose isomerase-like TIM barrel
22 252 InterPro IPR013022 Xylose isomerase-like, TIM barrel domain
1 271 Gene3D G3DSA:3.20.20.150 -
26 272 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
4 269 SUPERFAMILY SSF51658 Xylose isomerase-like
4 269 InterPro IPR036237 Xylose isomerase-like superfamily
15 25 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
2 241 PANTHER PTHR12110 HYDROXYPYRUVATE ISOMERASE

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GNI5
AlphaFold — — full sequence — Viewing
ColabFold KP13_03695
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
13 0.359
1 0.343

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 8.54 0.456