Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: KP13_03699
Assembly: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene: AHE46036.1
Status: annotated
Amino acids: 194
Structure source: AlphaFold + ColabFold

GO

GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0000166 Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Human identity (%): 0.0
Gut microbiome off-target: hit
Essential (DEG): Y
DEG identity (%): 41.875
DEG E-value: 6.97e-32
Localization: Cytoplasmic
ColabFold pLDDT: 85.41

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.125

Structure W8VHV5

Pocket Pocket 14

P2Rank 0.004

Structure W8VHV5

Pocket Pocket 1

ColabFold model

FPocket 0.078 · Pocket 7

Core conservation Conserved core gene

Roary core

CoreCruncher core

Gut microbiome 166 / 4744 genomes with a hit

Normalized 0.035

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2

GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
GO:0000166 Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records

Show feature table

Start	End	DB	Term	Name
40	128	Gene3D	G3DSA:3.30.70.990	-
40	128	InterPro	IPR035570	UPF0234, N-terminal
32	194	PANTHER	PTHR30476	UNCHARACTERIZED
32	194	InterPro	IPR007551	Protein of unknown function DUF520
129	194	FunFam	G3DSA:3.30.70.860:FF:000001	UPF0234 protein YajQ
129	194	Gene3D	G3DSA:3.30.70.860	-
129	194	InterPro	IPR035571	UPF0234-like, C-terminal
40	128	FunFam	G3DSA:3.30.70.990:FF:000001	UPF0234 protein YajQ
33	193	Pfam	PF04461	Protein of unknown function (DUF520)
33	193	InterPro	IPR007551	Protein of unknown function DUF520
33	120	SUPERFAMILY	SSF89963	YajQ-like
33	120	InterPro	IPR036183	YajQ-like superfamily
122	194	SUPERFAMILY	SSF89963	YajQ-like
122	194	InterPro	IPR036183	YajQ-like superfamily
33	193	CDD	cd11740	YajQ_like
32	194	Hamap	MF_00632	UPF0234 protein YajQ [yajQ].

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

No pockets are loaded yet for the displayed AlphaFold model AF_W8VHV5 structure. Run experimental pocket backfill to show FPocket/P2Rank overlays on this structure.

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold AF_W8VHV5	AlphaFold	—	—	full sequence	—	Viewing
ColabFold KP13_03699	ColabFold	—	—	full sequence	—	Loaded

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

1 records

Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.

No PDB structure with a co-crystallized ligand found for this exact protein.

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Ligand	Source crystal	UniProt (homolog)	MW · LogP · TPSA	Lipinski	PAINS	SMILES
MMC	1IN0	P44096	215.6 Da LogP 0.58 TPSA 0.0	✓ Ro5	✓ Clean	`C[Hg+]`

Experimental bioactivity from ChEMBL measured directly on this protein. Score = pchembl (−log Ki/IC₅₀; higher = more potent).

No ChEMBL bioactivity data found for this exact protein.

Bioactivity inferred from similar proteins in ChEMBL. Score = pchembl (−log Ki/IC₅₀; higher = more potent).

No ChEMBL hits found through similar proteins.

Proposed virtual-screening candidates from ZINC. Score = Tanimoto similarity to a known binder (0–1; higher = more similar).

No virtual-screening candidates for this protein.

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.

KP13_03699