Protein profile

KP13_02047

Transcriptional repressor nrdR

Genome: KpKP13

Gene: nrdR AHE46050.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GKD7
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Amino acids 141
Annotations 4
Features 10
PDB binders 0
Druggability 0.682

Overview

Basic information about this protein and its source genome.

Accession
KP13_02047
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
nrdR AHE46050.1
Status
annotated
Amino acids
141
Structure source
AlphaFold + ColabFold
GO
GO:0008270 Binding to a zinc ion (Zn). GO:0045892 Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
49.242
DEG E-value
1.87e-36
Localization
Cytoplasmic
ColabFold pLDDT
90.45

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.682
Structure A0A0H3GKD7
Pocket Pocket 1
P2Rank 0.309
Structure A0A0H3GKD7
Pocket Pocket 1
ColabFold model
FPocket 0.428 · Pocket 1
P2Rank 0.332 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 538 / 4744 genomes with a hit
Normalized 0.113

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0008270 Binding to a zinc ion (Zn).
  • GO:0045892 Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records
Show feature table
Start End DB Term Name
1 141 Hamap MF_00440 Transcriptional repressor NrdR [nrdR].
1 141 InterPro IPR003796 Ribonucleotide reductase regulator NrdR-like
42 128 Pfam PF03477 ATP cone domain
42 128 InterPro IPR005144 ATP-cone domain
41 131 ProSiteProfiles PS51161 ATP-cone domain profile.
41 131 InterPro IPR005144 ATP-cone domain
2 139 NCBIfam TIGR00244 transcriptional regulator NrdR
2 139 InterPro IPR003796 Ribonucleotide reductase regulator NrdR-like
2 141 PANTHER PTHR30455 TRANSCRIPTIONAL REPRESSOR NRDR
2 141 InterPro IPR003796 Ribonucleotide reductase regulator NrdR-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GKD7
AlphaFold — — full sequence — Viewing
ColabFold KP13_02047
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.682
4 0.479

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 5.33 0.252