Protein profile

KP13_02054

Preprotein translocase subunit

Genome: KpKP13

Gene: AHE46057.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GNG0
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Amino acids 120
Annotations 2
Features 19
PDB binders 0
Druggability 0.646

Overview

Basic information about this protein and its source genome.

Accession
KP13_02054
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46057.1
Status
annotated
Amino acids
120
Structure source
AlphaFold + ColabFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015031 The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
97.273
DEG E-value
3.81e-75
Localization
CytoplasmicMembrane
ColabFold pLDDT
81.98

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.646
Structure A0A0H3GNG0
Pocket Pocket 2
P2Rank
Structure A0A0H3GNG0
Pocket No pockets
ColabFold model
FPocket 0.145 · Pocket 2
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 145 / 4744 genomes with a hit
Normalized 0.031

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0015031 The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Sequence Features

Domain/signature hits from InterPro and related databases.

19 records
Show feature table
Start End DB Term Name
16 20 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
50 120 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1 20 Phobius SIGNAL_PEPTIDE Signal peptide region
29 112 NCBIfam TIGR00739 preprotein translocase subunit YajC
29 112 InterPro IPR003849 Preprotein translocase YajC
1 7 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
21 29 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
30 49 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
29 112 SMART SM01323 YajC_2
8 15 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
27 49 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
32 109 Pfam PF02699 Preprotein translocase subunit
32 109 InterPro IPR003849 Preprotein translocase YajC
27 115 PANTHER PTHR33909 SEC TRANSLOCON ACCESSORY COMPLEX SUBUNIT YAJC
27 115 InterPro IPR003849 Preprotein translocase YajC
31 51 PRINTS PR01853 Bacterial YajC preprotein translocase signature
31 51 InterPro IPR003849 Preprotein translocase YajC
69 87 PRINTS PR01853 Bacterial YajC preprotein translocase signature
69 87 InterPro IPR003849 Preprotein translocase YajC

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GNG0
AlphaFold — — full sequence — Viewing
ColabFold KP13_02054
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.646
7 0.464