Protein profile

KP13_02058

Acyl carrier protein phosphodiesterase

Genome: KpKP13

Gene: acpH AHE46061.1 Structure source: ColabFold

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Amino acids 172

Annotations 2

Features 6

PDB binders 0

Druggability 0.349

Overview

Basic information about this protein and its source genome.

Accession: KP13_02058
Assembly: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene: acpH AHE46061.1
Status: annotated
Amino acids: 172
Structure source: ColabFold

GO:0006633 The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. GO:0008770 Catalysis of the reaction: [acyl-carrier protein] + H2O = 4'-phosphopantetheine + apoprotein.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Human identity (%): 0.0
Gut microbiome off-target: hit
Essential (DEG): N
DEG identity (%): 0.0
Localization: Cytoplasmic
ColabFold pLDDT: 94.29

Selected Druggability evidence

ColabFold / curated model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.349

Structure CB_KP13_02058

Pocket Pocket 6

P2Rank 0.9

Structure CB_KP13_02058

Pocket Pocket 1

ColabFold model

FPocket 0.349 · Pocket 6

P2Rank 0.9 · Pocket 1

Core conservation Conserved core gene

Roary core

CoreCruncher core

Gut microbiome 111 / 4744 genomes with a hit

Normalized 0.023

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

GO:0006633 The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.
GO:0008770 Catalysis of the reaction: [acyl-carrier protein] + H2O = 4'-phosphopantetheine + apoprotein.

Sequence Features

Domain/signature hits from InterPro and related databases.

6 records

Show feature table

Start	End	DB	Term	Name
60	164	Pfam	PF04336	Acyl carrier protein phosphodiesterase
60	164	InterPro	IPR007431	Acyl carrier protein phosphodiesterase
1	172	PIRSF	PIRSF011489	UCP011489
1	172	InterPro	IPR007431	Acyl carrier protein phosphodiesterase
1	171	PANTHER	PTHR38764	ACYL CARRIER PROTEIN PHOSPHODIESTERASE
1	171	InterPro	IPR007431	Acyl carrier protein phosphodiesterase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
ColabFold KP13_02058	ColabFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
6				0.349

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK	Score	Probability
1	17.95	0.811
2	8.95	0.479
3	2.03	0.045