Protein profile

KP13_02066

antibiotic biosynthesis monooxygenase

Genome: KpKP13

Gene: AHE46069.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GKB7
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Amino acids 181
Annotations 0
Features 14
PDB binders 0
Druggability 0.721

Overview

Basic information about this protein and its source genome.

Accession
KP13_02066
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46069.1
Status
annotated
Amino acids
181
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
84.31

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.721
Structure A0A0H3GKB7
Pocket Pocket 10
P2Rank 0.069
Structure A0A0H3GKB7
Pocket Pocket 1
ColabFold model
FPocket 0.59 · Pocket 9
P2Rank 0.087 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 38 / 4744 genomes with a hit
Normalized 0.008

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
156 178 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
142 152 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
119 141 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
6 95 Gene3D G3DSA:3.30.70.100 -
2 180 PANTHER PTHR40057 SLR1162 PROTEIN
2 180 InterPro IPR038762 Antibiotic biosynthesis monooxygenase, predicted
153 175 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 118 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
176 181 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
8 78 Pfam PF03992 Antibiotic biosynthesis monooxygenase
8 78 InterPro IPR007138 Antibiotic biosynthesis monooxygenase domain
119 141 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
4 96 SUPERFAMILY SSF54909 Dimeric alpha+beta barrel
4 96 InterPro IPR011008 Dimeric alpha-beta barrel

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GKB7
AlphaFold — — full sequence — Viewing
ColabFold KP13_02066
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
10 0.721
5 0.438
6 0.211

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.37 0.063
2 1.82 0.035
3 1.21 0.011