Protein profile

KP13_02070

Maltodextrin glucosidase

Genome: KpKP13

Gene: AHE46073.1 malZ Structure source: AlphaFold + ColabFold UniProt A0A0H3GJ07
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Amino acids 605
Annotations 4
Features 17
PDB binders 5
Druggability 0.524

Overview

Basic information about this protein and its source genome.

Accession
KP13_02070
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46073.1 malZ
Status
annotated
Amino acids
605
Structure source
AlphaFold + ColabFold
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005975 The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0004553 Catalysis of the hydrolysis of any O-glycosyl bond. GO:0004558 Catalysis of the hydrolysis of terminal, non-reducing alpha-(1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
24.384
Human E-value
7.44e-15
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
97.09

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.524
Structure A0A0H3GJ07
Pocket Pocket 5
P2Rank 0.891
Structure A0A0H3GJ07
Pocket Pocket 1
ColabFold model
FPocket 0.395 · Pocket 16
P2Rank 0.936 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 81 / 4744 genomes with a hit
Normalized 0.017

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0005975 The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
  • GO:0004553 Catalysis of the hydrolysis of any O-glycosyl bond.
  • GO:0004558 Catalysis of the hydrolysis of terminal, non-reducing alpha-(1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records
Show feature table
Start End DB Term Name
122 531 CDD cd11338 AmyAc_CMD
127 521 SMART SM00642 aamy
127 521 InterPro IPR006047 Glycosyl hydrolase, family 13, catalytic domain
4 104 Pfam PF02903 Alpha amylase, N-terminal ig-like domain
4 104 InterPro IPR004185 Glycoside hydrolase, family 13, N-terminal Ig-like domain
530 603 SUPERFAMILY SSF51011 Glycosyl hydrolase domain
605 605 Coils Coil Coil
524 603 Gene3D G3DSA:2.60.40.1180 -
524 603 InterPro IPR013780 Glycosyl hydrolase, all-beta
117 530 SUPERFAMILY SSF51445 (Trans)glycosidases
117 530 InterPro IPR017853 Glycoside hydrolase superfamily
94 570 PANTHER PTHR10357 ALPHA-AMYLASE FAMILY MEMBER
177 493 Pfam PF00128 Alpha amylase, catalytic domain
177 493 InterPro IPR006047 Glycosyl hydrolase, family 13, catalytic domain
131 523 Gene3D G3DSA:3.20.20.80 Glycosidases
1 601 PIRSF PIRSF036918 Maltodextrin_glucosidase
1 601 InterPro IPR017069 Maltodextrin glucosidase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GJ07
AlphaFold — — full sequence — Viewing
ColabFold KP13_02070
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
5 0.524
40 0.029
4 0.012
3 0.004

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 28.73 0.891
2 5.59 0.222
3 4.58 0.163
4 2.86 0.073
5 1.21 0.01

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

35 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
ACG
1LWJ
P80099 791.8 Da LogP -9.71 TPSA 380.1 3 viol. ✓ Clean C[C@@H]1[C@H]([C@@H]([C@H]([C@H](O1)O[C@@H]2[C@…
ARE
3A6O
Q08751 807.7 Da LogP -10.74 TPSA 400.3 3 viol. ✓ Clean C[C@@H]1[C@H]([C@@H]([C@H]([C@H](O1)O[C@@H]2[C@…
FLC
6WNI
U5CJP3 189.1 Da LogP -5.25 TPSA 140.6 ✓ Ro5 ✓ Clean C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O
NOJ
5WCZ
O06994 163.2 Da LogP -2.97 TPSA 93.0 ✓ Ro5 ✓ Clean C1[C@@H]([C@H]([C@@H]([C@H](N1)CO)O)O)O
PRU
3WY1
H3K096 290.3 Da LogP 0.75 TPSA 149.2 ✓ Ro5 ✓ Clean C[C@H](C[C@H](C[C@@H](CCC(=O)O)C(=O)O)C(=O)O)C(…

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.