Protein profile

KP13_02090

Anti-adapter protein iraP

Genome: KpKP13

Gene: iraP AHE46092.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GNX2
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Amino acids 86
Annotations 2
Features 5
PDB binders 0
Druggability 0.866

Overview

Basic information about this protein and its source genome.

Accession
KP13_02090
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
iraP AHE46092.1
Status
annotated
Amino acids
86
Structure source
AlphaFold + ColabFold
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0009267 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
87.96

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.866
Structure A0A0H3GNX2
Pocket Pocket 7
P2Rank
Structure A0A0H3GNX2
Pocket No pockets
ColabFold model
FPocket 0.651 · Pocket 3
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 62 / 4744 genomes with a hit
Normalized 0.013

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0009267 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment.

Sequence Features

Domain/signature hits from InterPro and related databases.

5 records
Show feature table
Start End DB Term Name
1 86 Hamap MF_01198 Anti-adapter protein IraP [iraP].
1 86 InterPro IPR019732 Sigma-S stabilisation anti-adaptor protein
5 32 Coils Coil Coil
1 85 Pfam PF10796 Sigma-S stabilisation anti-adaptor protein
1 85 InterPro IPR019732 Sigma-S stabilisation anti-adaptor protein

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GNX2
AlphaFold — — full sequence — Viewing
ColabFold KP13_02090
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
7 0.866
6 0.565