Protein profile

KP13_02104

putative acyltransferase

Genome: KpKP13

Gene: AHE46104.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GNB3
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Amino acids 572
Annotations 4
Features 12
PDB binders 0
Druggability 0.96

Overview

Basic information about this protein and its source genome.

Accession
KP13_02104
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46104.1
Status
annotated
Amino acids
572
Structure source
AlphaFold + ColabFold
EC
2.3.2.30
GO
GO:0016746 Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). GO:0043810 Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + L-ornithine = lyso-ornithine lipid + [acyl-carrier protein]. The enzyme, found in bacteria, catalyzes the first step in the biosynthesis of ornithine lipids. GO:0006629 The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
90.65

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.96
Structure A0A0H3GNB3
Pocket Pocket 18
P2Rank 0.868
Structure A0A0H3GNB3
Pocket Pocket 1
ColabFold model
FPocket 0.539 · Pocket 6
P2Rank 0.884 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 60 / 4744 genomes with a hit
Normalized 0.013

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 3 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

3
  • GO:0016746 Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor).
  • GO:0043810 Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + L-ornithine = lyso-ornithine lipid + [acyl-carrier protein]. The enzyme, found in bacteria, catalyzes the first step in the biosynthesis of ornithine lipids.
  • GO:0006629 The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
269 566 PANTHER PTHR37323 GCN5-RELATED N-ACETYLTRANSFERASE
310 483 SUPERFAMILY SSF55729 Acyl-CoA N-acyltransferases (Nat)
310 483 InterPro IPR016181 Acyl-CoA N-acyltransferase
40 262 SUPERFAMILY SSF69593 Glycerol-3-phosphate (1)-acyltransferase
322 422 Pfam PF13444 Acetyltransferase (GNAT) domain
54 256 CDD cd07986 LPLAT_ACT14924-like
54 256 InterPro IPR045746 Putative acyltransferase ACT14924-like, acyltransferase domain
303 445 Gene3D G3DSA:3.40.630.30 -
29 247 Pfam PF19576 Acyltransferase
29 247 InterPro IPR045746 Putative acyltransferase ACT14924-like, acyltransferase domain
77 194 SMART SM00563 plsc_2
77 194 InterPro IPR002123 Phospholipid/glycerol acyltransferase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GNB3
AlphaFold — — full sequence — Viewing
ColabFold KP13_02104
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
18 0.96
6 0.888

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 15.51 0.755
2 10.18 0.547
3 9.78 0.526
4 7.33 0.383
5 2.39 0.063