Protein profile

KP13_02113

Ethanolamine ammonia-lyase light chain

Genome: KpKP13

Gene: AHE46113.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GNA2
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Amino acids 258
Annotations 7
Features 12
PDB binders 1
Druggability 0.482

Overview

Basic information about this protein and its source genome.

Accession
KP13_02113
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE46113.1
Status
annotated
Amino acids
258
Structure source
AlphaFold + ColabFold
EC
4.3.1.7
GO
GO:0006520 The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups. GO:0008851 Catalysis of the reaction: ethanolamine = acetaldehyde + NH4+. GO:0009350 An enzyme complex that catalyzes the breakdown of ethanolamine to form acetaldehyde and ammonia. GO:0031471 An organelle found in bacteria consisting of a proteinaceous coat containing enzymes for the degradation of ethanolamine whose purpose is the protection of the rest of the cell from the toxic acetaldehyde product of the enzyme ethanolamine ammonia lyase. GO:0031419 Binding to cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. GO:0046336 The chemical reactions and pathways resulting in the breakdown of ethanolamine (2-aminoethanol), an important water-soluble base of phospholipid (phosphatidylethanolamine).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
93.63

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.482
Structure A0A0H3GNA2
Pocket Pocket 8
P2Rank 0.023
Structure A0A0H3GNA2
Pocket Pocket 1
ColabFold model
FPocket 0.429 · Pocket 10
P2Rank 0.011 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 56 / 4744 genomes with a hit
Normalized 0.012

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 6 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

6
  • GO:0006520 The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups.
  • GO:0008851 Catalysis of the reaction: ethanolamine = acetaldehyde + NH4+.
  • GO:0009350 An enzyme complex that catalyzes the breakdown of ethanolamine to form acetaldehyde and ammonia.
  • GO:0031471 An organelle found in bacteria consisting of a proteinaceous coat containing enzymes for the degradation of ethanolamine whose purpose is the protection of the rest of the cell from the toxic acetaldehyde product of the enzyme ethanolamine ammonia lyase.
  • GO:0031419 Binding to cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.
  • GO:0046336 The chemical reactions and pathways resulting in the breakdown of ethanolamine (2-aminoethanol), an important water-soluble base of phospholipid (phosphatidylethanolamine).

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
1 249 PIRSF PIRSF018982 EutC
1 249 InterPro IPR009246 Ethanolamine ammonia-lyase small subunit
3 241 Hamap MF_00601 Ethanolamine ammonia-lyase small subunit [eutC].
3 241 InterPro IPR009246 Ethanolamine ammonia-lyase small subunit
61 240 Gene3D G3DSA:3.40.50.11240 -
61 240 InterPro IPR042251 Ethanolamine ammonia-lyase light chain, C-terminal
1 49 Gene3D G3DSA:1.10.30.40 -
1 49 InterPro IPR042255 Ethanolamine ammonia-lyase light chain, N-terminal
4 240 PANTHER PTHR39330 ETHANOLAMINE AMMONIA-LYASE LIGHT CHAIN
4 240 InterPro IPR009246 Ethanolamine ammonia-lyase small subunit
5 239 Pfam PF05985 Ethanolamine ammonia-lyase light chain (EutC)
5 239 InterPro IPR009246 Ethanolamine ammonia-lyase small subunit

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GNA2
AlphaFold — — full sequence — Viewing
ColabFold KP13_02113
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
8 0.482

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.49 0.021

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

3 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
ETA
3ABO
P19636 61.1 Da LogP -1.06 TPSA 46.2 ✓ Ro5 ✓ Clean C(CO)N

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.